NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
Specificity
Natural and recombinant Rat NAD-dependent deacetylase sirtuin-2
Subcellular Location
Cytoplasm cytoskeleton Colocalizes with microtubules.