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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Mothers against decapentaplegic homolog 2

SKU : BHE13810869

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2184r
Alternative Names	Mad-related protein 2 ; SMAD family member 2 ; SMAD 2 ; Madh2
Categories	Elisa
Function	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
Specificity	Natural and recombinant Rat Mothers against decapentaplegic homolog 2
Subcellular Location	Cytoplasm Nucleus Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Detection Range	0.625-40ng/mL
Entryname	SMAD2_RAT
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 2
Sensitivity	0.316ng/mL
Sequence	50: MSSILPFTPP ; VVKRLLGWKK ; SAGGSGGAGG ; GEQNGQEEKW ; CEKAVKSLVK ; 100: KLKKTGRLDE ; LEKAITTQNC ; NTKCVTIPST ; CSEIWGLSTA ; NTVDQWDTTG ; 150: LYSFSEQTRS ; LDGRLQVSHR ; KGLPHVIYCR ; LWRWPDLHSH ; HELKAIENCE ; 200: YAFSLKKDEV ; CVNPYHYQRV ; ETPVLPPVLV ; PRHTEILTEL ; PPLDDYTHSI ; 250: PENTNFPAGI ; EPQSNYIPET ; PPPGYISEDG ; ETSDQQLNQS ; MDTGSPAELS ; 300: PTTLSPVNHS ; LDLQPVTYSE ; PAFWCSIAYY ; ELNQRVGETF ; HASQPSLTVD ; 350: GFTDPSNSER ; FCLGLLSNVN ; RNATVEMTRR ; HIGRGVRLYY ; IGGEVFAECL ; 400: SDSAIFVQSP ; NCNQRYGWHP ; ATVCKIPPGC ; NLKIFNNQEF ; AALLAQSVNQ ; 450: GFEAVYQLTR ; MCTIRMSFVK ; GWGAEYRRQT ; VTSTPCWIEL ; HLNGPLQWLD ; 467: KVLTQMGSPS ; VRCSSMS
Sequence Length	467
String	O70436
Sub Unit	Momomer; the absence of TGF-beta (By similarity). Heterodimer; in the presence of TGF-beta. Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with ACVR1B, SMAD3 and TRIM33. Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300 and SKI. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts (via PY-motif) with SMURF2. Interacts with AIP1 and HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with SKOR1 and SKOR2. Interacts with PRDM16. Interacts (via MH2 domain) with LEMD3. Interacts with RBPMS. Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination ot the TGF-beta signaling. Interacts with PML.

Uniprot	O70436
Gene Name	Smad2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29357
Unigene	Rn.2755

Reference	1. "Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A." Zhang Y.-Q., Kanzaki M., Furukawa M., Shibata H., Ozeki M., Kojima I. Diabetologia42:719-727(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Brain. 2. "cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes." Osaki M., Tsukazaki T., Ono N., Yonekura A., Hirota Y., Miyazaki Y., Shindo H., Sonta S., Yamashita S. Endocr. J.46:695-701(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Molecular cloning of rat Smad2 gene." Miyakita A., Okuno S., Watanabe T.K., Oga K., Tsuji A., Hishigaki H., Kato S., Sano A., Suto T., Nakagawa K., Nakahara Y., Haraguchi N., Higashi K. Submitted (1998-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Testis. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810869	E2184r	96T	$796		Add to Cart

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