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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Mothers against decapentaplegic homolog 1

SKU : BHE13810548

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0647r
Alternative Names	SMAD family member 1 ; SMAD 1 ; Mad1 ; Madh1
Categories	Elisa
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
Specificity	Natural and recombinant Rat Mothers against decapentaplegic homolog 1
Subcellular Location	Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
Detection Range	0.312-20ng/mL
Entryname	SMAD1_RAT
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 1
Sensitivity	0.159ng/mL
Sequence	50: MNVTSLFSFT ; SPAVKRLLGW ; KQGDEEEKWA ; EKAVDALVKK ; LKKKKGAMEE ; 100: LEKALSCPGQ ; PSNCVTIPRS ; LDGRLQVSHR ; KGLPHVIYCR ; VWRWPDLQSH ; 150: HELKPLECCE ; FPFGSKQKEV ; CINPYHYKRV ; ESPVLPPVLV ; PRHSEYNPQH ; 200: SLLAQFRNLG ; QNEPHMPLNA ; TFPDSFQQPH ; SHPFAQYPNS ; SYPNSPGSSS ; 250: STYPHSPTSS ; DPGSPFQMPA ; DTPPPAYLPP ; EDPMAQDGSQ ; PMDTNMTNMT ; 300: APTLPAEINR ; GDVQAVAYEE ; PKHWCSIVYY ; ELNNRVGERF ; HASSTSVLVD ; 350: GFTDPSNNKN ; RFCLGLLSNV ; NRNSTIENTR ; RHIGKGVHLY ; YVGGEVYAEC ; 400: LSDSSIFVQS ; RNCNYHHGFH ; PTTVCKIPSG ; CSLKIFNNQE ; FAQLLAQSVN ; 450: HGFETEYELT ; KMCTIRMSFV ; KGWGAEYHRQ ; DVTSTPCWIE ; IHLHGPLQWL ; 468: DKVLTQMGSP ; HNPISSVS
Sequence Length	468
String	P97588
Sub Unit	May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), NANOG, p300, SMURF1, SMURF2, HOXC8 and HGS. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1 and ZCCHC12. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Uniprot	P97588
Gene Name	Smad1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.10635

Reference	1. "Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins." Chen Y., Lebrun J.-J., Vale W.W. Proc. Natl. Acad. Sci. U.S.A.93:12992-12997(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Cloning and expression of a rat Smad1: regulation by TGFbeta and modulation by the Ras/MEK pathway." Yue J., Hartsough M.T., Frey R.S., Frielle T., Mulder K.M. J. Cell. Physiol.178:387-396(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Intestine.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810548	E0647r	96T	$796		Add to Cart

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