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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Mitogen-activated protein kinase 8

SKU : BHE13806922

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9092r
Alternative Names	SAPK gamma ; Stress-activated protein kinase JNK1 ; c-Jun N-terminal kinase 1 ; p54 gamma ; Jnk1 ; Prkm8
Categories	Elisa
Function	Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4).
Specificity	Natural and recombinant Rat Mitogen-activated protein kinase 8
Detection Range	0.312-20ng/mL
Entryname	MK08_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Mitogen-activated protein kinase 8
Sensitivity	0.165ng/mL
Sequence	50: MSRSKRDNNF ; YSVEIADSTF ; TVLKRYQNLK ; PIGSGAQGIV ; CAAYDAILER ; 100: NVAIKKLSRP ; FQNQTHAKRA ; YRELVLMKCV ; NHKNIIGLLN ; VFTPQKSLEE ; 150: FQDVYIVMEL ; MDANLCQVIQ ; MELDHERMSY ; LLYQMLCGIK ; HLHSAGIIHR ; 200: DLKPSNIVVK ; SDCTLKILDF ; GLARTAGTSF ; MMTPYVVTRY ; YRAPEVILGM ; 250: GYKENVDLWS ; VGCIMGEMVC ; LKILFPGRDY ; IDQWNKVIEQ ; LGTPCPEFMK ; 300: KLQPTVRTYV ; ENRPKYAGYS ; FEKLFPDVLF ; PADSEHNKLK ; ASQARDLLSK ; 350: MLVIDASKRI ; SVDEALQHPY ; INVWYDPSEA ; EAPPPKIPDK ; QLDEREHTIE ; 400: EWKELIYKEV ; MDLEERTKNG ; VIRGQPSPLG ; AAVINGSQHP ; VSSPSVNDMS ; 411: SMSTDPTLAS ; D
Sequence Length	411
String	P49185
Sub Unit	Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53, WWOX and JAMP. Interacts with NFATC4. Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells. Interacts with MECOM; regulates JNK signaling (By similarity). Forms a complex with MAPK8IP1 and RGNEF.

Uniprot	P49185
Gene Name	Mapk8
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:116554
Unigene	Rn.4090

Reference	1. "The stress-activated protein kinase subfamily of c-Jun kinases." Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., Woodgett J.R. Nature369:156-160(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses." Clerk A., Fuller S.J., Michael A., Sugden P.H. J. Biol. Chem.273:7228-7234(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR tissue: Heart. 3. "Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation." Park H.S., Huh S.H., Kim M.S., Lee S.H., Choi E.J. Proc. Natl. Acad. Sci. U.S.A.97:14382-14387(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-116;MUTAGENESIS OF CYS-116 4. "Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein." Wu J., Zhai J., Lin H., Nie Z., Ge W.-W., Garcia-Bermejo L., Muschel R.J., Schlaepfer W.W., Canete-Soler R. Brain Res. Mol. Brain Res.117:27-38(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH MAPK8IP1 AND ARHGEF28 5. "JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length." Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J., Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T. J. Cell Biol.173:265-277(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPK8IP1; STMN2; STMN3 AND STMN4;SUBCELLULAR LOCATION 6. "Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate." Westerlund N., Zdrojewska J., Padzik A., Komulainen E., Bjorkblom B., Rannikko E., Tararuk T., Garcia-Frigola C., Sandholm J., Nguyen L., Kallunki T., Courtney M.J., Coffey E.T. Nat. Neurosci.14:305-313(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806922	E9092r	96T	$796		Add to Cart

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