ELISA Kit for Rat Melanocortin receptor 4

Mfr.No.	E11964r
Categories	Elisa
Function	Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.
Specificity	Natural and recombinant Rat Melanocortin receptor 4
Subcellular Location	Cell membrane Multi-pass membrane protein
Detection Range	0.312-20ng/mL
Entryname	MC4R_RAT
Method Type	Sandwich
Platform	PF00001
Protein Name	Melanocortin receptor 4
Sensitivity	0.103ng/mL
Sequence	50: MNSTHHHGMY ; TSLHLWNRSS ; HGLHGNASES ; LGKGHSDGGC ; YEQLFVSPEV ; 100: FVTLGVISLL ; ENILVIVAIA ; KNKNLHSPMY ; FFICSLAVAD ; MLVSVSNGSE ; 150: TIVITLLNST ; DTDAQSFTVN ; IDNVIDSVIC ; SSLLASICSL ; LSIAVDRYFT ; 200: IFYALQYHNI ; MTVRRVGIII ; SCIWAACTVS ; GVLFIIYSDS ; SAVIICLITM ; 250: FFTMLVLMAS ; LYVHMFLMAR ; LHIKRIAVLP ; GTGTIRQGAN ; MKGAITLTIL ; 300: IGVFVVCWAP ; FFLHLLFYIS ; CPQNPYCVCF ; MSHFNLYLIL ; IMCNAVIDPL ; 332: IYALRSQELR ; KTFKEIICFY ; PLGGICELPG ; RY
Sequence Length	332
String	P70596
Sub Unit	Interacts with ATRNL1 (By similarity). Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.

Reference	1. "Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction." Alvaro J.D., Tatro J.B., Quillan J.M., Fogliano M., Eisenhard M., Lerner M.R., Nestler E.J., Duman R.S. Mol. Pharmacol.50:583-591(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13806919	E11964r	96T	$796		Add to Cart