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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Malignant T-cell-amplified sequence 1

SKU : BHE13806939

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15021r
Categories	Elisa
Function	Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
Specificity	Natural and recombinant Rat Malignant T-cell-amplified sequence 1
Subcellular Location	Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	MCTS1_RAT
Method Type	Sandwich
Platform	PF01472
Protein Name	Malignant T-cell-amplified sequence 1
Sensitivity	0.059ng/mL
Sequence	50: MGKGRFDEKE ; NVSNCIQLKT ; SVIKGIKNQL ; LEQFPGIEPW ; LNQIMPKKDP ; 100: VKIVRCHEHI ; EILTVNGELL ; FFRQREGPFY ; PTLRLLHKYP ; FILPHQQVDK ; 150: GAIKFVLSGA ; NIMCPGLTSP ; GAKLYPAAVD ; TIVAIMAEGK ; QHALCVGVMK ; 182: MSAEDIEKVN ; KGIGIENIHY ; LNDGLWHMKT ; YK
Sequence Length	182
String	Q4G009
Sub Unit	Interacts (via PUA domain) with DENR.

Uniprot	Q4G009
Gene Name	Mcts1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:302500
Unigene	Rn.36129

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Spleen.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806939	E15021r	96T	$796		Add to Cart

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