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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Leukocyte-associated immunoglobulin-like receptor 1

SKU : BHE13805589

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9027r
Alternative Names	CD305
Categories	Elisa
Function	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Specificity	Natural and recombinant Rat Leukocyte-associated immunoglobulin-like receptor 1
Subcellular Location	Membrane Single-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	LAIR1_RAT
Method Type	Sandwich
Protein Name	Leukocyte-associated immunoglobulin-like receptor 1
Sensitivity	0.083ng/mL
Sequence	50: MPLHSVIVLV ; LVLCLGWKSN ; TQEESLSDFT ; ICAEPGPVIP ; QGNFITIVCS ; 100: TSGEYDTVRL ; EKEGSTFMEK ; KTEPHGKQHR ; FRIGPVNETI ; TGYYNCIFEK ; 150: NYVWSQRSND ; LQLKVIKENV ; TQGLAPGPSM ; TSDTSWLKTY ; SIHILTVVSV ; 200: IFLLCLSLFL ; FCFLSHRQKK ; QGLPNNKSQH ; QRSQERLNLA ; TNGLEKTSDI ; 250: VMDDSLSEDR ; QTETWTPVAG ; DLQEVTYAQL ; DHDSLTQRTV ; KDVTPQNRVI ; 263: MAESSTYAAI ; MRC
Sequence Length	263
String	P0C1X9
Sub Unit	Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK.

Uniprot	P0C1X9
Gene Name	Lair1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:574531
Unigene	Rn.149608

Reference	1. "Identification and characterization of the rat homologue of LAIR-1." Lebbink R.J., de Ruiter T., Kaptijn G.J.A., Meyaard L. Immunogenetics57:344-351(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DOMAIN ITIM MOTIF;TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805589	E9027r	96T	$796		Add to Cart

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