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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Interleukin-4 receptor subunit alpha

SKU : BHE13806510

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2031r
Alternative Names	CD124 ; Il4ra
Categories	Elisa
Function	Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.
Specificity	Natural and recombinant Rat Interleukin-4 receptor subunit alpha
Subcellular Location	Isoform 2 Secreted
Detection Range	31.2-2000pg/mL
Entryname	IL4RA_RAT
Method Type	Sandwich
Platform	PF09238
Protein Name	Interleukin-4 receptor subunit alpha
Sensitivity	15.82pg/mL
Sequence	50: MGWLCTKFLS ; SVSCLILLWV ; TGSGGIKVLG ; DPTCFSDYIR ; TSTCEWQLDS ; 100: TVDCSSQLLL ; DYRLLFEFSE ; NLTCTPKNSA ; DTVCVCQMAI ; EEPIQADTYW ; 150: LELWSERGQL ; WQGSFKPSDN ; VKPPAPDNLT ; LHTNVSNALL ; LMWSNPYPSN ; 200: NFLHKGLICM ; VNISREDNPA ; EFKVYNVTYT ; EPKLSFPVNT ; LTSGVRYRAR ; 250: VRVLSQSFPG ; IWSEWSPSIT ; WYNHFQLPLL ; QRLPLGVSIS ; CICILLFCLT ; 300: CYFSIIKIKK ; IWWDQIPTPA ; RSPLAAIIIQ ; DTKVSLWEKQ ; TRSQESTKSR ; 350: HWKTCLTKLL ; PCLLEHRVKK ; ERESPKAAKT ; KPLQSPEKAG ; WYPAEVSRTV ; 400: LWPENVHVSV ; VRCMELFEAP ; VQNVEEEEDE ; MVKGDLSMSP ; ENSGGGFQES ; 450: QADIMARLTE ; NLFSDLLGAE ; NGGVGQSSMA ; ESSSLLPSES ; GQASTSWACF ; 500: PTGPSETTCQ ; VTGQQPPHPD ; PERATGTACT ; QVPLVISDNP ; AYRSFSDFSS ; 550: PAPNPGELAS ; EQKQAGHLEE ; GDLLSPVDPH ; SSGPPMQQAE ; SWEQILHMSV ; 600: LQHGTAGSTP ; APTSGYQEFV ; QAVKQGASQD ; AGVPGVGPSG ; DTGYKAFSSL ; 650: LSSSGVCTDT ; AAAGTDSGCG ; GYKPFQNPVP ; NQSPNSMPLF ; TFGLDMELPP ; 700: SPLNSAPPNS ; TPECLGLELG ; LKGGTWLKAP ; PPSEQVPKPF ; GDDLGLGIVY ; 750: SSLTCHLCGH ; LKQHHSQEED ; GQIHVVASPG ; CGCCYDEKSP ; SLGNLSGTLE ; 800: SCPGEMSQEA ; NLTLAPRTPS ; NLSGVGKGPG ; HSPVPSQTTE ; VPVGTLGVTV ; 801: S
Sequence Length	801
String	Q63257
Sub Unit	The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region (By similarity). In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Uniprot	Q63257
Gene Name	Il4r
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25084
Unigene	Rn.10471

Reference	1. "The rat interleukin 4 receptor: coevolution of ligand and receptor." Richter G., Hein G., Blankenstein T., Diamantstein T. Cytokine7:237-241(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: Wistar. tissue: Spleen. 2. "Identification of soluble interleukin-4 receptor in rat glomerular epithelial cells." Chen G., Nagasawa R., Imasawa T., Eto Y., Kikuchi K., Maruyama N. Biochim. Biophys. Acta1452:79-88(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2) tissue: Kidney.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806510	E2031r	96T	$796		Add to Cart

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