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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

SKU : BHE13803203

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1135r
Alternative Names	Eukaryotic translation initiation factor 2-alpha kinase 2 ; eIF-2A protein kinase 2 ; Interferon-inducible RNA-dependent protein kinase ; Protein kinase RNA-activated ; PKR ; Tyrosine-protein kinase EIF2AK2 ; 2.7.10.2 ; Prkr
Categories	Elisa
Function	Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
Specificity	Natural and recombinant Rat Interferon-induced, double-stranded RNA-activated protein kinase
Detection Range	0.312-20ng/mL
Entryname	E2AK2_RAT
Method Type	Sandwich
Platform	PF00035
Protein Name	Interferon-induced, double-stranded RNA-activated protein kinase
Sensitivity	0.158ng/mL
Sequence	50: MASDTPGFYV ; DKLNKYSQIH ; KVKIIYKEIS ; VTGPPHDRRF ; TFQVIIEERE ; 100: FPEGEGRSKQ ; EAKNNAAKLA ; VEILDNENKV ; DSHTDASEQG ; LIEGNYIGLV ; 150: NSFAQKENLP ; VNFELCDPDS ; QLPHRFICKC ; KIGQTTYGTG ; FGANKKEAKQ ; 200: LAAKNAYQKL ; SEKSPSKTGF ; VTSLSSDFSS ; SSSITSNSAS ; QSASGRDFED ; 250: IFMNGLREKR ; KSGVKVPSDD ; VLRNKYTLDD ; RFSKDFEDIE ; EIGSGGFGQV ; 300: FKAKHRIDGK ; TYAIKRITYN ; TKKAKREVQA ; LAELNHANIV ; QYRVCWEGED ; 350: YDYDPENSTN ; GDTSRYKTRC ; LFIQMEFCDK ; GTLQQWLEKR ; NRSQEDKALV ; 400: LELFEQIVTG ; VDYIHSKGLI ; HRDLKPGNIF ; LVDEKHIKIG ; DFGLATALEN ; 450: DGNPRTKYTG ; TPQYMSPEQK ; SSLVEYGKEV ; DIFALGLILA ; ELLHICKTDS ; 500: EKIEFFQLLR ; NGIFSDDIFD ; NKEKSLLQKL ; LSSKPRERPN ; TSEILKTLAE ; 513: WKNISEKKKR ; NTC
Sequence Length	513
Sub Unit	Homodimer (By similarity). Interacts with DNAJC3 (By similarity). Interacts with STRBP. Forms a complex with FANCA, FANCC, FANCG and HSP70.

Uniprot	Q63184
Gene Name	Eif2ak2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:54287
Unigene	Rn.10022

Reference	1. "Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase." Mellor H., Flowers K.M., Kimball S.R., Jefferson L.S. Biochim. Biophys. Acta1219:693-696(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Brain. 2. "A new double-stranded RNA-binding protein that interacts with PKR." Coolidge C.J., Patton J.G. Nucleic Acids Res.28:1407-1417(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STRBP 3. "Blocking the eIF2? kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory." Stern E., Chinnakkaruppan A., David O., Sonenberg N., Rosenblum K. J. Neurosci.33:2517-2525(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803203	E1135r	96T	$796		Add to Cart

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