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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Insulin receptor

SKU : BHE13806693

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0895r
Alternative Names	CD220
Categories	Elisa
Function	This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K).
Specificity	Natural and recombinant Rat Insulin receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.312-20ng/mL
Entryname	INSR_RAT
Method Type	Sandwich
Platform	PF00041
Protein Name	Insulin receptor
Sensitivity	0.159ng/mL
Sequence	50: MGSGRGCETT ; AVPLLMAVAV ; AGGTAGHLYP ; GEVCPGMDIR ; NNLTRLHELE ; 100: NCSVIEGHLQ ; ILLMFKTRPE ; DFRDLSFPKL ; IMITDYLLLF ; RVYGLESLKD ; 150: LFPNLTVIRG ; SRLFFNYALV ; IFEMVHLKEL ; GLYNLMNITR ; GSVRIEKNNE ; 200: LCYLATIDWS ; RILDYVEDNY ; IVLNKDDNEE ; CGDVCPGTAK ; GKTNCPATVI ; 250: NGQFVERCWT ; HSHCQKVCPT ; ICKSHGCTAE ; GLCCHKECLG ; NCSEPDDPTK ; 300: CVACRNFYLD ; GQCVETCPPP ; YYHFQDWRCV ; NFSFCQDLHY ; KCRNSRKPGC ; 350: HQYVIHNNKC ; IPECPSGYTM ; NSSNLMCTPC ; LGPCPKVCQI ; LEGEKTIDSV ; 400: TSAQELRGCT ; VINGSLIINI ; RGGNNLAAEL ; EANLGLIEEI ; SGFLKIRRSY ; 450: ALVSLSFFRK ; LHLIRGETLE ; IGNYSFYALD ; NQNLRQLWDW ; NKHNLTITQG ; 500: KLFFHYNPKL ; CLSEIHKMEE ; VSGTKGRQER ; NDIALKTNGD ; QASCENELLK ; 550: FSFIRTSFDK ; ILLRWEPYWP ; PDFRDLLGFM ; LFYKEAPYQN ; VTEFDGQDAC ; 600: GSNSWTVVDI ; DPPQRSNDPK ; SQTPSHPGWL ; MRGLKPWTQY ; AIFVKTLVTF ; 650: SDERRTYGAK ; SDIIYVQTDA ; TNPSVPLDPI ; SVSNSSSQII ; LKWKPPSDPN ; 700: GNITHYLVYW ; ERQAEDSELF ; ELDYCLKGLK ; LPSRTWSPPF ; ESDDSQKHNQ ; 750: SEYDDSASEC ; CSCPKTDSQI ; LKELEESSFR ; KTFEDYLHNV ; VFVPRKTSSG ; 800: NGAEDTRPSR ; KRRSLEEVGN ; VTATTPTLPD ; FPNISSTIAP ; TSHEEHRPFE ; 850: KVVNKESLVI ; SGLRHFTGYR ; IELQACNQDS ; PEERSGVAAY ; VSARTMPEAK ; 900: ADDIVGPVTH ; EIFENNVVHL ; MWQEPKEPNG ; LIVLYEVSYR ; RYGDEELHLC ; 950: VSRKHFALER ; GCRLRGLSPG ; NYSVRVRATS ; LAGNGSWTEP ; TYFYVTDYLD ; 1000: VPSNIAKIII ; GPLIFVFLFS ; VVIGSIYLFL ; RKRQPDGPMG ; PLYASSNPEY ; 1050: LSASDVFPSS ; VYVPDEWEVP ; REKITLLREL ; GQGSFGMVYE ; GNAKDIIKGE ; 1100: VETRVAVKTV ; NESASLRERI ; EFLNEASVMK ; GFTCHHVVRL ; LGVVSKGQPT ; 1150: LVVMELMAHG ; DLKSHLRSLR ; PDAENNPGRP ; PPTLQEMIQM ; TAEIADGMAY ; 1200: LNAKKFVHRD ; LAARNCMVAH ; DFTVKIGDFG ; MTRDIYETDY ; YRKGGKGLLP ; 1250: VRWMSPESLK ; DGVFTASSDM ; WSFGVVLWEI ; TSLAEQPYQG ; LSNEQVLKFV ; 1300: MDGGYLDPPD ; NCPERLTDLM ; RMCWQFNPKM ; RPTFLEIVNL ; LKDDLHPSFP ; 1350: EVSFFYSEEN ; KAPESEELEM ; EFEDMENVPL ; DRSSHCQREE ; AGCREGGSSL ; 1383: SIKRTYDEHI ; PYTHMNGGKK ; NGRVLTLPRS ; NPS
Sequence Length	1383
String	P15127
Sub Unit	Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2. Interacts with IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. The sequences surrounding the phosphorylated NPEY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K/PIK3R1 in vitro when autophosphorylated on tyrosine residues. Interacts with SOCS7 (By similarity). Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with 'Tyr-27' phosphorylation of CAV2. Interacts with ARRB2 (By similarity). Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling (By similarity). Interacts with GRB7.

Uniprot	P15127
Gene Name	Insr
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.9876

Reference	1. "The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing." Goldstein B.J., Dudley A.L. Mol. Endocrinol.4:235-244(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);ALTERNATIVE SPLICING (ISOFORM SHORT) 2. Liu Y., Tam J.W.O. Submitted (1997-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 731-756; 758-819; 969-994 AND 1119-1177 strain: Sprague-Dawley. 3. "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2." Kasus-Jacobi A., Bereziat V., Perdereau D., Girard J., Burnol A.F. Oncogene19:2052-2059(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7 4. "Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells." Johansson G.S., Arnqvist H.J. Am. J. Physiol.291:E1124-E1130(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH IGF1R 5. "Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis." Kwon H., Jeong K., Pak Y. J. Cell. Mol. Med.13:1549-1564(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAV2

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