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ELISA Kit for Rat Inhibitor of nuclear factor kappa-B kinase subunit beta

SKU : BHE13805568

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1953r
Alternative Names	I-kappa-B kinase 2 ; IKK2 ; Nuclear factor NF-kappa-B inhibitor kinase beta ; NFKBIKB ; Ikkb
Categories	Elisa
Function	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Specificity	Natural and recombinant Rat Inhibitor of nuclear factor kappa-B kinase subunit beta
Subcellular Location	Cytoplasm Nucleus Membrane raft Colocalized with DPP4 in membrane rafts.
Detection Range	0.312-20ng/mL
Entryname	IKKB_RAT
Method Type	Sandwich
Platform	PF12179
Protein Name	Inhibitor of nuclear factor kappa-B kinase subunit beta
Sensitivity	0.156ng/mL
Sequence	50: MSWSPSLPTQ ; TCGAWEMKER ; LGTGGFGNVI ; RWHNQVTGEQ ; IAIKQCRQEL ; 100: SPKNRDRWCL ; EIQIMRRLNH ; PNVVAARDVP ; EGMQNLAPND ; LPLLAMEYCQ ; 150: GGDLRRYLNQ ; FENCCGLREG ; AILTLLSDIA ; SALRYLHENR ; IIHRDLKPEN ; 200: IVLQQGEKRL ; IHKIIDLGYA ; KELDQGSLCT ; SFVGTLQYLA ; PELLEQQKYT ; 250: VTVDYWSFGT ; LAFECITGFR ; PFLPNWQPVQ ; WHSKVRQKSE ; VDIVVSEDLN ; 300: GTVKFSSSSP ; FPNNLNSVLA ; ERLEKWLQLM ; LTWQPRQRGV ; DPQYGPNGCF ; 350: RALDDILNLK ; LVHILNMVTG ; TIHTYPVMED ; ESLQSLKTRI ; REDTGILETD ; 400: QELLQEAGLV ; LLPDKPATQC ; ISDSKTNEGL ; TLDMDLVFLF ; DNSKMSYETQ ; 450: ITPRPQPESV ; SCVLQEPKRN ; LSFFQMRKVW ; GQVWHSIQTL ; KEDCNRLQQG ; 500: QRAAMMNLLR ; NNSCLSKMKN ; AMASTAQQLK ; AKLDFFKTSI ; QIDLEKYREQ ; 550: TEFGITSDKL ; LLAWREMEQA ; VEQCGRENDV ; KVLVERMMAL ; QTDIVDLQRS ; 600: PMGRKQGGTL ; DDLEEQAREL ; YRRLREKPRD ; QRTEGDSQDM ; VRLLLQAIQS ; 650: FEKKVRVIYS ; QLSKTVVCKQ ; KALELLPKVE ; EVVRLMNEDE ; KTVVRLQEKR ; 700: QKELWNLLKI ; ACSKVRGPVS ; GSPDSMNVSR ; LSHPGHLMSQ ; PSSACDSLPD ; 750: SDKKSEELVA ; EAHALCSRLE ; SALQDTVKQQ ; DRSFTTLDWS ; WLQMEDEERC ; 757: GLEQACD
Sequence Length	757
String	Q9QY78
Sub Unit	Component of the I-kappa-B-kinase (IKK) canonical complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with FAF1; the interaction disrupts the IKK complex formation. Interacts with ATM. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with TRIM21 (By similarity). Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity.

Uniprot	Q9QY78
Gene Name	Ikbkb
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:84351
Unigene	Rn.19222

Reference	1. "IKK beta in megakaryocyte differentiation." Zhang Y., Sun S., Ravid K. Submitted (1998-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase." Nemoto S., DiDonato J.A., Lin A. Mol. Cell. Biol.18:7336-7343(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IKK PHOSPHORYLATION 3. "The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination." Wooten M.W., Geetha T., Seibenhener M.L., Babu J.R., Diaz-Meco M.T., Moscat J. J. Biol. Chem.280:35625-35629(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1; PRKCI AND TRAF6 4. "The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection." Jobin C., Sartor R.B. Am. J. Physiol.278:C451-C462(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805568	E1953r	96T	$796		Add to Cart

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