ELISA Kit for Rat Histone deacetylase 8

Mfr.No.	E1111r
Categories	Elisa
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in smooth muscle cell contractility.
Specificity	Natural and recombinant Rat Histone deacetylase 8
Subcellular Location	Nucleus Cytoplasm
Detection Range	0.78-50ng/mL
Entryname	HDAC8_RAT
Method Type	Sandwich
Platform	PF00850
Protein Name	Histone deacetylase 8
Sensitivity	0.19ng/mL
Sequence	50: MEIPEEPANS ; GHSLPPVYIY ; SPEYVSICDS ; LVKVPKRASM ; VHSLIEAYAL ; 100: HKQMRIVKPK ; VASMEEMATF ; HTDAYLQHLQ ; KVSQEGDEDH ; PDSIEYGLGY ; 150: DCPATEGIFD ; YAAAIGGGTI ; TAAQCLIDGK ; CKVAINWSGG ; WHHAKKDEAS ; 200: GFCYLNDAVL ; GILRLRRKFD ; RILYVDLDLH ; HGDGVEDAFS ; FTSKVMTVSL ; 250: HKFSPGFFPG ; TGDMSDVGLG ; KGRYYSVNVP ; IQDGIQDEKY ; YHICESVLKE ; 300: VYQAFNPKAV ; VLQLGADTIA ; GDPMCSFNMT ; PVGIGKCLKY ; VLQWQLATLI ; 350: LGGGGYNLAN ; TARCWTYLTG ; VILGKTLSSE ; IPDHEFFTAY ; GPDYVLEITP ; 377: SCRPDRNEPH ; RIQQILNYIK ; GNLKHVV
Sequence Length	377
Sub Unit	Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Spleen.

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