JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Histone deacetylase 1

SKU : BHE13804760

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0883r
Categories	Elisa
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
Specificity	Natural and recombinant Rat Histone deacetylase 1
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	HDAC1_RAT
Method Type	Sandwich
Platform	PF00850
Protein Name	Histone deacetylase 1
Sensitivity	0.081ng/mL
Sequence	50: MAQTQGTKRK ; VCYYYDGDVG ; NYYYGQGHPM ; KPHRIRMTHN ; LLLNYGLYRK ; 100: MEIYRPHKAN ; AEEMTKYHSD ; DYIKFLRSIR ; PDNMSEYSKQ ; MQRFNVGEDC ; 150: PVFDGLFEFC ; QLSTGGSVAS ; AVKLNKQQTD ; IAVNWAGGLH ; HAKKSEASGF ; 200: CYVNDIVLAI ; LELLKYHQRV ; LYIDIDIHHG ; DGVEEAFYTT ; DRVMTVSFHK ; 250: YGEYFPGTGD ; LRDIGAGKGK ; YYAVNYPLRD ; GIDDESYEAI ; FKPVMSKVME ; 300: MFQPSAVVLQ ; CGSDSLSGDR ; LGCFNLTIKG ; HAKCVEFVKS ; FNLPMLMLGG ; 350: GGYTIRNVAR ; CWTYETAVAL ; DTEIPNELPY ; NDYFEYFGPD ; FKLHISPSNM ; 400: TNQNTNEYLE ; KIKQRLFENL ; RMLPHAPGVQ ; MQAIPEDAIP ; EESGDEDEED ; 450: PDKRISICSS ; DKRIACEEEF ; SDSDEEGEGG ; RKNSSNFKKA ; KRVKTEDEKE ; 482: KDPEEKKEVT ; EEEKTKEEKP ; EAKGVKEEVK ; MA
Sequence Length	482
String	Q4QQW4
Sub Unit	Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BAZ2A/TIP5, BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SMYD2, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with BANP, CBFA2T3 and KDM5B. Interacts with E4F1, SAMSN1 and KLF1. Interacts with CHFR, PRDM16, SP1, SP3, and SMAD3. Interacts with RB1 and SMARCA4/BRG1. Interacts with TRAF6. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1 (By similarity). Interacts with NR4A2/NURR1 and BRMS1. Interacts with C10orf90/FATS (via its N-terminal); the interaction prevents binding of HDAC1 to the CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21; the interaction is prevented by binding of C10orf90/FATS facilitating acetylation and stabilization of CDKN1A/p21. Binds to CDK5 complexed to CDK5R (p25).

Uniprot	Q4QQW4
Gene Name	Hdac1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:297893
Unigene	Rn.1863

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Placenta. 2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13804760	E0883r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.