ELISA Kit for Rat Gremlin-1

Mfr.No.	E2130r
Alternative Names	Cysteine knot superfamily 1 ; BMP antagonist 1 ; Down-regulated in Mos-transformed cells protein ; Cktsf1b1 ; Drm
Categories	Elisa
Function	Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
Specificity	Natural and recombinant Rat Gremlin-1
Subcellular Location	Secreted
Detection Range	0.156-10ng/mL
Entryname	GREM1_RAT
Method Type	Sandwich
Platform	PF03045
Protein Name	Gremlin-1
Sensitivity	0.088ng/mL
Sequence	50: MNRTAYTVGA ; LLLLLGTLLP ; AAEGKKKGSQ ; GAIPPPDKAQ ; HNDSEQTQSP ; 100: PQPGSRTRGR ; GQGRGTAMPG ; EEVLESSQEA ; LHVTERKYLK ; RDWCKTQPLK ; 150: QTIHEEGCNS ; RTIINRFCYG ; QCNSFYIPRH ; IRKEEGSFQS ; CSFCKPKKFT ; 184: TMMVTLNCPE ; LQPPTKKKRV ; TRVKQCRCIS ; IDLD
Sequence Length	184
String	O35793
Sub Unit	Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.

Reference	1. "Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture." Topol L.Z., Marx M., Laugier D., Bogdanova N.N., Boubnov N.V., Clausen P.A., Calothy G., Blair D.G. Mol. Cell. Biol.17:4801-4810(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION 2. "Bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis." Chen B., Blair D.G., Plisov S., Vasiliev G., Perantoni A.O., Chen Q., Athanasiou M., Wu J.Y., Oppenheim J.J., Yang D. J. Immunol.173:5914-5917(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLIT1 AND SLIT2;FUNCTION;MUTAGENESIS OF 42-ASN--SER-44

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BHE13804851	E2130r	96T	$796		Add to Cart