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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Glycogen synthase kinase-3 alpha

SKU : BHE13805606

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0767r
Alternative Names	Factor A ; FA ; Serine/threonine-protein kinase GSK3A ; 2.7.11.1
Categories	Elisa
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.
Specificity	Natural and recombinant Rat Glycogen synthase kinase-3 alpha
Detection Range	0.312-20ng/mL
Entryname	GSK3A_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	Glycogen synthase kinase-3 alpha
Sensitivity	0.161ng/mL
Sequence	50: MSGGGPSGGG ; PGGSGRARTS ; SFAEPGGGGG ; GGGGGPGGSA ; SGPGGTGGGK ; 100: ASVGAMGGGV ; GASSSGGGPS ; GSGGGGSGGP ; GAGTSFPPPG ; VKLGRDSGKV ; 150: TTVVATLGQG ; PERSQEVAYT ; DIKVIGNGSF ; GVVYQARLAE ; TRELVAIKKV ; 200: LQDKRFKNRE ; LQIMRKLDHC ; NIVRLRYFFY ; SSGEKKDELY ; LNLVLEYVPE ; 250: TVYRVARHFT ; KAKLIIPIIY ; VKVYMYQLFR ; SLAYIHSQGV ; CHRDIKPQNL ; 300: LVDPDTAVLK ; LCDFGSAKQL ; VRGEPNVSYI ; CSRYYRAPEL ; IFGATDYTSS ; 350: IDVWSAGCVL ; AELLLGQPIF ; PGDSGVDQLV ; EIIKVLGTPT ; REQIREMNPN ; 400: YTEFKFPQIK ; AHPWTKVFKS ; RTPPEAIALC ; SSLLEYTPSS ; RLSPLEACAH ; 450: SFFDELRSLG ; TQLPNNRPLP ; PLFNFSPGEL ; SIQPSLNAIL ; IPPHLRSPSG ; 483: PATLTSSSQA ; LTETQTGQDW ; QAPDATPTLT ; NSS
Sequence Length	483
String	P18265
Sub Unit	Monomer. Interacts with ARRB2, AXIN1 and CTNNB1/beta-catenin.

Uniprot	P18265
Gene Name	Gsk3a
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:50686
Unigene	Rn.36807

Reference	1. "Molecular cloning and expression of glycogen synthase kinase-3/factor A." Woodgett J.R. EMBO J.9:2431-2438(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Brain. 2. "Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation." Hughes K., Nikolakaki E., Plyte S.E., Totty N.F., Woodgett J.R. EMBO J.12:803-808(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-279 3. "Inhibition of GSK3 promotes replication and survival of pancreatic beta cells." Mussmann R., Geese M., Harder F., Kegel S., Andag U., Lomow A., Burk U., Onichtchouk D., Dohrmann C., Austen M. J. Biol. Chem.282:12030-12037(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF PANCREATIC BETA-CELLS

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805606	E0767r	96T	$796		Add to Cart

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