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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat G1/S-specific cyclin-D1

SKU : BHE13801665

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0585r
Categories	Elisa
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Specificity	Natural and recombinant Rat G1/S-specific cyclin-D1
Subcellular Location	Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Detection Range	0.312-20ng/mL
Entryname	CCND1_RAT
Method Type	Sandwich
Platform	PF02984
Protein Name	G1/S-specific cyclin-D1
Sensitivity	0.163ng/mL
Sequence	50: MEHQLLCCEV ; ETIRRAYPDT ; NLLNDRVLRA ; MLKTEETCAP ; SVSYFKCVQR ; 100: EIVPSMRKIV ; ATWMLEVCEE ; QKCEEEVFPL ; AMNYLDRFLS ; LEPLKKSRLQ ; 150: LLGATCMFVA ; SKMKETIPLT ; AEKLCIYTDN ; SIRPEELLQM ; ELLLVNKLKW ; 200: NLAAMTPHDF ; IEHFLSKMPE ; ADENKQIIRK ; HAQTFVALCA ; TDVKFISNPP ; 250: SMVAAGSVVA ; AMQGLNLGSP ; NNFLSCYRTT ; HFLSRVIKCD ; PDCLRACQEQ ; 295: IEALLESSLR ; QAQQNIDPKA ; TEEEGEVEEE ; AGLACTPTDV ; RDVDI
Sequence Length	295
String	P39948
Sub Unit	Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2 and FBXO4.

Uniprot	P39948
Gene Name	Ccnd1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:58919
Unigene	Rn.22279

Reference	1. "Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1." Tamura K., Kanaoka Y., Jinno S., Nagata A., Ogiso Y., Shimizu K., Hayakawa T., Nojima H., Okayama H. Oncogene8:2113-2118(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Kidney. 2. "Calcium modulates the cyclin D1 expression in a rat parathyroid cell line." Bianchi S., Fabiani S., Muratori M., Arnold A., Sakaguchi K., Miki T., Brandi M.L. Biochem. Biophys. Res. Commun.204:691-700(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801665	E0585r	96T	$796		Add to Cart

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