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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Frizzled-8

SKU : BHE13804594

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1714r
Categories	Elisa
Function	Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Specificity	Natural and recombinant Rat Frizzled-8
Subcellular Location	Membrane Multi-pass membrane protein Golgi apparatus Cell membrane Multi-pass membrane protein Colocalizes with GOPC at the Golgi apparatus.
Detection Range	0.156-10ng/mL
Entryname	FZD8_RAT
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-8
Sensitivity	0.088ng/mL
Sequence	50: MEWGYLLEVT ; SLLAALAVLQ ; RSSGAAAASA ; KELACQEITV ; PLCKGIGYNY ; 100: TYMPNQFNHD ; TQDEAGLEVH ; QFWPLVEIQC ; SPDLKFFLCS ; MYTPICLEDY ; 150: KKPLPPCRSV ; CERAKAGCAP ; LMRQYGFAWP ; DRMRCDRLPE ; QGNPDTLCMD ; 200: YNRTDLTTAA ; PSPPRRLPPP ; QPGEQPPSGS ; GHSRPPGARP ; PHRGGSSRGS ; 250: GDTAAAPPSR ; GGKARPPGGG ; AAPCEPGCQC ; RAPMVSVSSE ; RHPLYNRVKT ; 300: GQIANCALPC ; HNPFFSQDER ; AFTVFWIGLW ; SVLCFVSTFA ; TVSTFLIDME ; 350: RFKYPERPII ; FLSACYLFVS ; VGYLVRLVAG ; HEKVACSGGA ; PGAGGAGGAG ; 400: GAATAGAGAA ; GAGASSPGAR ; GEYEELGAVE ; QHVRYETTGP ; ALCTVVFLLV ; 450: YFFGMASSIW ; WVILSLTWFL ; AAGMKWGNEA ; IAGYSQYFHL ; AAWLVPSVKS ; 500: IAVLALSSVD ; GDPVAGICYV ; GNQSLDNLRG ; FVLAPLVIYL ; FIGTMFLLAG ; 550: FVSLFRIRSV ; IKQQGGPTKT ; HKLEKLMIRL ; GLFTVLYTVP ; AAVVVACLFY ; 600: EQHNRPRWEA ; THNCPCLRDL ; QPDQARRPDY ; AVFMLKYFMC ; LVVGITSGVW ; 650: VWSGKTLESW ; RALCTRCCWA ; SKGAAVGAGA ; GGSGPGGGGP ; GPGGGGGHGG ; 684: GGGSLYSDVS ; TGLTWRSGTA ; SSVSYPKQMP ; LSQV
Sequence Length	684
String	Q498S8
Sub Unit	Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts (via the PDZ-binding motif) with GPOC (via its PDZ domain). Interacts with RSPO1 and RSPO3.

Uniprot	Q498S8
Gene Name	Fzd8
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:364754
Unigene	Rn.234505

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804594	E1714r	96T	$796		Add to Cart

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