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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Frizzled-4

SKU : BHE13805003

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9388r
Alternative Names	CD344
Categories	Elisa
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Specificity	Natural and recombinant Rat Frizzled-4
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Detection Range	1.56-100ng/mL
Entryname	FZD4_RAT
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-4
Sensitivity	0.781ng/mL
Sequence	50: MAWQGTGPSV ; RGMPGGVRLR ; LGLLLLQLLL ; LQRPALGFGD ; EEERRCDPIR ; 100: IAMCQNLGYN ; VTKMPNLVGH ; ELQTDAELQL ; TTFTPLIQYG ; CSSQLQFFLC ; 150: SVYVPMCTEK ; INIPIGPCGG ; MCLSVKRRCE ; PVLKEFGFAW ; PDSLNCSKFP ; 200: PQNDHNHMCM ; EGPGDEEVPL ; PHKTPIQPGE ; ECHSVGTNSD ; QYIWVKRSLN ; 250: CVLKCGYDAG ; LYSRSAKEFT ; DIWMAVWASL ; CFISTTFTVL ; TFLIDSSRFS ; 300: YPERPIIFLS ; MCYNIYSIAY ; IVRLTVGRER ; ISCDFEEAAE ; PVLIQEGLKN ; 350: TGCAIIFLLM ; YFFGMASSIW ; WVILTLTWFL ; AAGLKWGHEA ; IEMHSSYFHI ; 400: AAWAIPAVKT ; IVILIMRLVD ; ADELTGLCYV ; GNQSLDALTG ; FVVAPLFTYL ; 450: VIGTLFIAAG ; LVALFKIRSN ; LQKDGTKTDK ; LERLMVKIGV ; FSVLYTVPAT ; 500: CVIACYFYEI ; SNWALFRYSA ; DDSNMAVEML ; KIFMSLLVGI ; TSGMWIWSAK ; 538: TLHTWQKCSN ; RLVNSGKVKR ; EKRGNGWVKP ; GKGNETVV
Sequence Length	538
String	Q9QZH0
Sub Unit	Interacts with MAGI3 and NDP. Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP).

Uniprot	Q9QZH0
Gene Name	Fzd4
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:64558
Unigene	Rn.18388

Reference	1. "Expression of a putative seven-pass transmembrane frizzled receptor in the Corpus Luteum (CL) of the rat during pregnancy and involution." Walther P.R., Lacher M.D., Saurer S., Friis R.R. Submitted (1999-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Corpus luteum.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805003	E9388r	96T	$796		Add to Cart

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