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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Frizzled-1

SKU : BHE13804700

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11110r
Categories	Elisa
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.
Specificity	Natural and recombinant Rat Frizzled-1
Subcellular Location	Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
Detection Range	0.78-50ng/mL
Entryname	FZD1_RAT
Method Type	Sandwich
Platform	PF01534
Protein Name	Frizzled-1
Sensitivity	0.2ng/mL
Sequence	50: MAEEAVPSES ; RAAGRPSLEL ; CAVALPGRRE ; EVGHQDTAGH ; RRPRAHSRCW ; 100: ARGLLLLLWL ; LEAPLLLGVR ; AQPAGQVSGP ; GQQRPPPPQP ; QQGGQQYNGE ; 150: RGISIPDHGY ; CQPISIPLCT ; DIAYNQTIMP ; NLLGHTNQED ; AGLEVHQFYP ; 200: LVKVQCSAEL ; KFFLCSMYAP ; VCTVLEQALP ; PCRSLCERAQ ; GCEALMNKFG ; 250: FQWPDTLKCE ; KFPVHGAGEL ; CVGQNTSDKG ; TPTPSLLPEF ; WTSNPQHGGG ; 300: GYRGGYPGGA ; GPVERGKFSC ; PRALRVPSYL ; NYHFLGEKDC ; GAPCEPTKVY ; 350: GLMYFGPEEL ; RFSRTWIGIW ; SVLCCASTLF ; TVLTYLVDMR ; RFSYPERPII ; 400: FLSGCYTAVA ; VAYIAGFLLE ; DRVVCNDKFA ; EDGARTVAQG ; TKKEGCTILF ; 450: MMLYFFSMAS ; SIWWVILSLT ; WFLAAGMKWG ; HEAIEANSQY ; FHLAAWAVPA ; 500: IKTITILALG ; QVDGDVLSGV ; CFVGLNNVDA ; LRGFVLAPLF ; VYLFIGTSFL ; 550: LAGFVSLFRI ; RTIMKHDGTK ; TEKLEKLMVR ; IGVFSVLYTV ; PATIVIACYF ; 600: YEQAFRDQWE ; RSWVAQSCKS ; YAIPCPHLQG ; GGGVPPHPPM ; SPDFTVFMIK ; 641: YLMTLIVGIT ; SGFWIWSGKT ; LNSWRKFYTR ; LTNSKQGETT ; V
Sequence Length	641
String	Q08463

Uniprot	Q08463
Gene Name	Fzd1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.6575

Reference	1. "Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues." Chan S.D.H., Karpf D.B., Fowlkes M.E., Hooks M., Bradley M.S., Vuong V., Bambino T., Liu M.Y.C., Arnaud C.D., Strewler G.J., Nissenson R.A. J. Biol. Chem.267:25202-25207(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Osteosarcoma. 2. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner." Sheldahl L.C., Park M., Malbon C.C., Moon R.T. Curr. Biol.9:695-698(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COUPLING TO BETA-CATENIN PATHWAY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804700	E11110r	96T	$796		Add to Cart

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