ELISA Kit for Rat Free fatty acid receptor 1

Mfr.No.	E9934r
Alternative Names	G-protein coupled receptor 40 ; Gpr40
Categories	Elisa
Function	Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
Specificity	Natural and recombinant Rat Free fatty acid receptor 1
Subcellular Location	Cell membrane Multi-pass membrane protein
Detection Range	0.312-20ng/mL
Entryname	FFAR1_RAT
Method Type	Sandwich
Platform	PF00001
Protein Name	Free fatty acid receptor 1
Sensitivity	0.171ng/mL
Sequence	50: MDLPPQLSFA ; LYVSAFALGF ; PLNLLAIRGA ; VSHAKLRLTP ; SLVYTLHLAC ; 100: SDLLLAITLP ; LKAVEALASG ; VWPLPLPFCP ; VFALAHFAPL ; YAGGGFLAAL ; 150: SAGRYLGAAF ; PFGYQAIRRP ; CYSWGVCVAI ; WALVLCHLGL ; ALGLEAPRGW ; 200: VDNTTSSLGI ; NIPVNGSPVC ; LEAWDPDSAR ; PARLSFSILL ; FFLPLVITAF ; 250: CYVGCLRALV ; HSGLSHKRKL ; RAAWVAGGAL ; LTLLLCLGPY ; NASNVASFIN ; 300:
Sequence Length	300
String	Q8K3T4

Reference	1. "The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids." Briscoe C.P., Tadayyon M., Andrews J.L., Benson W.G., Chambers J.K., Eilert M.M., Ellis C., Elshourbagy N.A., Goetz A.S., Minnick D.T., Murdock P.R., Sauls H.R. Jr., Shabon U., Spinage L.D., Strum J.C., Szekeres P.G., Tan K.B., Way J.M., Ignar D.M., Wilson S., Muir A.I.more... J. Biol. Chem.278:11303-11311(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: Sprague-Dawley. 2. "Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40." Itoh Y., Kawamata Y., Harada M., Kobayashi M., Fujii R., Fukusumi S., Ogi K., Hosoya M., Tanaka Y., Uejima H., Tanaka H., Maruyama M., Satoh R., Okubo S., Kizawa H., Komatsu H., Matsumura F., Noguchi Y., Shinohara T., Hinuma S., Fujisawa Y., Fujino M.more... Nature422:173-176(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY

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BHE13803733	E9934r	96T	$796		Add to Cart