ELISA Kit for Rat Eukaryotic translation initiation factor 4E-binding protein 1

Mfr.No.	E2693r
Alternative Names	Phosphorylated heat- and acid-stable protein regulated by insulin 1 ; PHAS-I
Categories	Elisa
Function	Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Specificity	Natural and recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1
Detection Range	0.156-10ng/mL
Entryname	4EBP1_RAT
Method Type	Sandwich
Platform	PF05456
Protein Name	Eukaryotic translation initiation factor 4E-binding protein 1
Sensitivity	0.078ng/mL
Sequence	50: MSAGSSCSQT ; PSRAIPTRRV ; ALGDGVQLPP ; GDYSTTPGGT ; LFSTTPGGTR ; 100: IIYDRKFLME ; CRNSPVAKTP ; PKDLPTIPGV ; TSPTSDEPPM ; QASQSHLHSS ; 117: PEDKRAGGEE ; SQFEMDI
Sequence Length	117
String	Q62622
Sub Unit	Interacts with RPTOR (By similarity). Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation.

Reference	1. "Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors." Hu C., Pang S., Kong X., Velleca M., Lawrence J.C. Jr. Proc. Natl. Acad. Sci. U.S.A.91:3730-3734(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 18-33; 43-53; 62-80 AND 98-117;PHOSPHORYLATION;TISSUE SPECIFICITY strain: Sprague-Dawley. tissue: Adipocyte. tissue: Skeletal muscle. 2. "PHAS-I as a link between mitogen-activated protein kinase and translation initiation." Lin T.-A., Kong X., Haystead T.A.J., Pause A., Belsham G.J., Sonenberg N., Lawrence J.C. Jr. Science266:653-656(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EIF4E;PHOSPHORYLATION AT SER-64 BY MAPK1 AND MAPK3;MUTAGENESIS OF SER-64

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800059	E2693r	96T	$796		Add to Cart