Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
Specificity
Natural and recombinant Rat Eukaryotic translation initiation factor 2-alpha kinase 3
Subcellular Location
Endoplasmic reticulum membrane Single-pass type I membrane protein