Elongin 18 kDa subunit ; RNA polymerase II transcription factor SIII subunit B ; SIII p18 ; Transcription elongation factor B polypeptide 2 ; Tceb2
Categories
Elisa
Function
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, TCEB3, VHL or WSB1. Interacts with VHL.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-8; 12-28; 44-55 AND 69-89;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY