JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat E3 ubiquitin-protein ligase SIAH2

SKU : BHE13810765

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E5526r
Alternative Names	RING-type E3 ubiquitin transferase SIAH2 ; Seven in absentia homolog 2 ; Siah-2
Categories	Elisa
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.
Specificity	Natural and recombinant Rat E3 ubiquitin-protein ligase SIAH2
Subcellular Location	Cytoplasm Nucleus Predominantly cytoplasmic (Probable). Partially nuclear.
Entryname	SIAH2_RAT
Platform	PF03145
Protein Name	E3 ubiquitin-protein ligase SIAH2
Sequence	50: MSRPSSTGPS ; ANKPCSKQPP ; PPQTPHAPSP ; AAPPAAATIS ; AAGPGSSAVP ; 100: AAAAVISGPG ; AGGGAGPVSP ; QHHELTSLFE ; CPVCFDYVLP ; PILQCQAGHL ; 150: VCNQCRQKLS ; CCPTCRGALT ; PSIRNLAMEK ; VASAVLFPCK ; YATTGCSLTL ; 200: HHTEKPEHED ; ICEYRPYSCP ; CPGASCKWQG ; SLEAVMSHLM ; HAHKSITTLQ ; 250: GEDIVFLATD ; INLPGAVDWV ; MMQSCFGHHF ; MLVLEKQEKY ; EGHQQFFAIV ; 300: LLIGTRKQAE ; NFAYRLELNG ; NRRRLTWEAT ; PRSIHDGVAA ; AIMNSDCLVF ; 325: DTAIAHLFAD ; NGNLGINVTI ; STCCQ
Sequence Length	325
String	Q8R4T2
Sub Unit	Homodimer. Interacts with VAV1, without mediating its ubiquitin-mediated degradation. Probable component of some large E3 complex possibly composed of UBE2D1, SIAH2, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I and UBE2E2. Interacts with PEG10, which may inhibit its activity. Interacts with PEG3 and EGLN2 (By similarity). Interacts with SNCAIP.

Uniprot	Q8R4T2
Gene Name	Siah2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:140593
Unigene	Rn.29192

Reference	1. "Rat Siah1A." Yamaguchi A., Hori O., Tohyama M. Submitted (2001-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Regulation of synaptophysin degradation by mammalian homologues of Seven in Absentia." Wheeler T.C., Chin L.-S., Li Y., Roudabush F.L., Li L. J. Biol. Chem.277:10273-10282(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-325;FUNCTION IN SYP DEGRADATION;INTERACTION WITH UBE2E2 strain: Sprague-Dawley. 3. "Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease." Liani E., Eyal A., Avraham E., Shemer R., Szargel R., Berg D., Bornemann A., Riess O., Ross C.A., Rott R., Engelender S. Proc. Natl. Acad. Sci. U.S.A.101:5500-5505(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNCAIP 4. "Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation." Szargel R., Rott R., Eyal A., Haskin J., Shani V., Balan L., Wolosker H., Engelender S. J. Biol. Chem.284:11706-11716(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SNCAIP;TISSUE SPECIFICITY

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13810765	E5526r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.