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ELISA Kit for Rat DNA (cytosine-5)-methyltransferase 1

SKU : BHE13803172

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2102r
Alternative Names	DNA MTase RnoIP ; M.RnoIP ; DNA methyltransferase I ; MCMT
Categories	Elisa
Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Specificity	Natural and recombinant Rat DNA (cytosine-5)-methyltransferase 1
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	DNMT1_RAT
Method Type	Sandwich
Platform	PF01426
Protein Name	DNA (cytosine-5)-methyltransferase 1
Sensitivity	0.168ng/mL
Sequence	50: MPARTAPARV ; PALASPAGSL ; PDHVRRRLKD ; LERDGLTEKE ; CVKEKLNLLH ; 100: EFLQTEIKSQ ; LCDLETKLHK ; EELSEEGYLA ; KVKTLLNKDL ; CLENGTLSLT ; 150: QKANGCPANG ; SRPTWKAEMA ; DSNRSPRSRP ; KPRGPRRSKS ; DSETMIEASS ; 200: SSVATRRTTR ; QTTITSHFKG ; PAKRKPKEDS ; EKGNANESAA ; EERDQDKKRR ; 250: VAGTESRASR ; AGESVEKPER ; VRPGTQLCQE ; EQGEQEDDRR ; PRRQTRELAS ; 300: RRKSREDPDR ; EARPGTHLDV ; DDDDEKDKRS ; SRPRSQPRDL ; ATKRRPKEEV ; 350: EQITPEPPEG ; KDEDEREEKR ; RKTTRKKPEP ; LSIPVQSRVE ; RKASQGKASA ; 400: IPKLNPPQCP ; ECGQYLDDPD ; LKYQQHPVDA ; VDEPQMLTNE ; ALSVFDSNSS ; 450: WFETYDSSPM ; HKFTFFSVYC ; SRGHLCPVDT ; GLIEKNVELY ; FSGVAKAIHE ; 500: ENPSVEGGVN ; GKNLGPINQW ; WISGFDGGEK ; ALIGFSTAFA ; EYFLMEPSPE ; 550: YAPIFGLMQE ; KIYISKIVVE ; FLQSNPDAVY ; EDLINKIETT ; VPPSAINVNR ; 600: FTEDSLLRHA ; QFVVSQVESY ; DDAKDDDETP ; IFLSPCMRSL ; IHLAGVSLGQ ; 650: RRATRRTVIN ; SAKVKRKGPT ; KATTTKLVYQ ; IFDTFFSEQI ; EKDDKEDKEN ; 700: TMKRRRCGVC ; EVCQQPECGK ; CKACKDMVKF ; GGTGRSKQAC ; LKRRCPNLAV ; 750: KEADEDEEAD ; DDIPELPSPK ; KLHQGKKKKQ ; NKDRISWLGE ; PVKIEENRTY ; 800: YWKVSIDEET ; LEVGDCVSVI ; PDDPSKPLYL ; ARVTALWEDK ; NGQMFHAHWF ; 850: CAGTDTVLGA ; TSDPLELFLV ; GECENMQLSY ; IHSKVKVIYR ; GPSPNWAMEG ; 900: GMDPEAMLPG ; AEDGKTYFYQ ; FWYSQDYARF ; ESPPKTQPAE ; DNKHKFCLSC ; 950: IRLAELRQKE ; MPKVLEQLEE ; VDGRVYCSSI ; TKNGVVYRLG ; DSVYLPPEAF ; 1000: TFNIKMASPM ; KRSKRDPVNE ; NPVPRDTYRK ; YSDYIKGSNL ; DAPEPYRIGR ; 1050: IKEIYCGKKK ; GGKVNEADIK ; IRLYKFYRPE ; NTHKSIQATY ; HADINLLYWS ; 1100: DEEAVVDFSD ; VQGRCTVEYG ; EDLLESIQDY ; SQGGPDRFYF ; LEAYNSKTKS ; 1150: FEDPPNHARS ; PGNKGKGKGK ; GKGKGKPQVS ; EPKEPEAAIK ; LPKLRTLDVF ; 1200: SGCGGLTEGF ; HQAGISETLW ; AIEMWEPAAQ ; AFRLNNPGTT ; VFTEDCNVLL ; 1250: KLVMAGEVTN ; SLGQRLPQKG ; DVEMLCGGPP ; CQGFSGMNRF ; NSRTYSKFKN ; 1300: SLVVSFLSYC ; DYYRPRFFLL ; ENVRNFVSFR ; RSMVLKLTLR ; CLVRMGYQCT ; 1350: FGVLQAGQYG ; VAQTRRRAII ; LAAAPGEKLP ; LFPEPLHVFA ; PRACQLSVVV ; 1400: DDKKFVSNIT ; RLSSGPFRTI ; TMRDTMSDLP ; EIQNGASAPE ; ISYKWRATVL ; 1450: VPEAAARVAL ; PAHPQGPYPQ ; VHERAGGCRM ; RHIPLSPGSD ; WRDLPNIQVR ; 1500: LRDGVITNKL ; RYTFHDTKNG ; CSSTGALRGV ; CSCAEGKTCD ; PASRQFNTLI ; 1550: PWCLPHTGNR ; HNHWAGLYGR ; LEWDGFFSTT ; VTNPEPMGKQ ; GRVLHPEQHR ; 1600: VVSVRECARS ; QGFPDTYRLF ; GNILDRHRQV ; GNAVPPPLAK ; AIGLEIKLCL ; 1622: LASAQESASA ; AVKGKEETTT ; ED
Sequence Length	1622
String	Q9Z330
Sub Unit	Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B (By similarity). Binds annexin V (Potential). Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.

Uniprot	Q9Z330
Gene Name	Dnmt1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.6955

Reference	1. "Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase." Kimura H., Takeda T., Tanaka S., Ogawa T., Shiota K. Biochem. Biophys. Res. Commun.253:495-501(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: Sprague-Dawley. tissue: Brain. tissue: Placenta. 2. "Multiple N-terminal isoforms of DNA (cytosine-5-)-methyltransferase in vivo." Deng J., Szyf M. Submitted (1998-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-144 (ISOFORMS 1 AND 9) tissue: Brain. 3. "Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure." Ohsawa K., Imai Y., Ito D., Kohsaka S. J. Neurochem.67:89-97(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-356;IN VITRO BINDING TO ANNEXIN V strain: Wistar. tissue: Brain. 4. "Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene." Deng J., Szyf M. J. Biol. Chem.273:22869-22872(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1169-1517 (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8)

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