Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
Specificity
Natural and recombinant Rat Disintegrin and metalloproteinase domain-containing protein 17
"Sequence analysis of rat TNF-alpha converting enzyme (TACE) cDNA." Hall L., Beaumont A.J., Jury J.A., Frayne J. Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
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