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ELISA Kit for Rat Deleted in malignant brain tumors 1 protein

SKU : BHE13803078

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15081r
Alternative Names	Ebnerin ; Hensin ; Pancrin
Categories	Elisa
Function	May play roles in mucosal defense system, cellular immune defense and epithelial differentiation (By similarity). May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophages tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.
Specificity	Natural and recombinant Rat Deleted in malignant brain tumors 1 protein
Subcellular Location	Secreted Cytoplasmic vesicle secretory vesicle membrane Single-pass membrane protein Lumenal side Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells (By similarity). Formed in the ducts of von Ebner gland and released into the fluid bathing the taste buds contained in the taste papillae.
Detection Range	0.156-10ng/mL
Entryname	DMBT1_RAT
Method Type	Sandwich
Platform	PF00431
Protein Name	Deleted in malignant brain tumors 1 protein
Sensitivity	0.05ng/mL
Sequence	50: MGISIVIFEI ; CLLWGQILST ; ASQSRSSTPD ; WWNHGGTIND ; VIYDTQETPE ; 100: VTTTQVPDST ; SIGTDSGLAV ; RLVNGGDRCR ; GRVEILYQGS ; WGTMCDDGTD ; 150: SGLAVRLVNG ; GDRCRGRVEI ; LYQGSWGTMC ; DDSWDINDAN ; VVCRQLGCGW ; 200: ALSAPGSAQF ; GQGLGPIVLD ; DVACRGHEAY ; LWSCSHRGWL ; SHNCGHQEDA ; 250: GVICSDSQTS ; SPTPGWWNPG ; GTNNDVIYDT ; QETTETSQTS ; SPTPDWWNHG ; 300: GTINDVIYDT ; QETTEGTDSG ; LAVRLVNGGD ; RCRGRVEILY ; QGSWGTVCDD ; 350: SWDINDANVV ; CRQLGCGWAL ; SAPGSAQFGQ ; GSGSIVLDDV ; ACRGHEAYLW ; 400: SCSHRGWLSH ; NCGHQEDAGV ; ICSYSQTSSP ; TPDSQTSSPT ; PGWWNPGGTN ; 450: NDVSYGPEQT ; TDATDSGLAV ; RLVNGGDRCQ ; GRVEILYQGS ; WGTVCDDSWD ; 500: TKDANVVCRQ ; LVCGWALSAP ; GSAHFGQGSG ; SIVLDDVACT ; GHEAYLWSCS ; 550: HRGWLSHNCG ; HHEDAGVICS ; DAQTQSTTWP ; DMWPTTTPET ; TTDWWTTKYS ; 600: SSVPTTQFPT ; IADWWTTPSP ; EYTCGGLLTL ; PYGQFSSPYY ; PGSYPNNARC ; 650: LWKIFVSSMN ; RVTVVFTDVQ ; LEGGCNYDYI ; LVFDGPENNS ; SLIARVCDGF ; 700: NGSFTSTQNF ; MSVVFITDGS ; VTRRGFQADY ; YSTPISTSTT ; SPTTFPIVTD ; 750: WWTTPSPEYT ; CGGLLTLPYG ; QFSSPYYPGS ; YPNNARCLWK ; IFVPSMNRVT ; 800: VVFTDVQLEG ; GCNYDYILGF ; DGPEYNSSLI ; ARVCDGSNGS ; FTSTQNFMSV ; 850: VFITDGSVTR ; RGFQADYYST ; PIRTSTTPPT ; TFPIITGNDS ; SLVLRLVNGT ; 900: NRCEGRVEIL ; YRGSWVPCAD ; DSWDINDANV ; VCRQLGCGSA ; LSAPGNAWFG ; 950: QGSGLIVLDD ; VSCSGYESHL ; WNCRHPGWLV ; HNCRHVEDAG ; VICSLPDPTP ; 1000: SPGPVWTSPP ; FVNYTCGGFL ; TGLSGQFSSP ; YYPGSYPNNA ; RCLWNIEVPN ; 1050: NYRVTVVFRD ; VQLEGGCNYD ; YIEIFDGPHH ; SSPLIARVCD ; GAMGSFTSTS ; 1100: NFMSVRFTTD ; HSVTRRGFRA ; DYYSDFDNNT ; TNLLCLSNHM ; RASVSRSYLQ ; 1150: SMGYSSRDLV ; IPGWNVSYQC ; QPQITQREVI ; FTIPYTGCGT ; TKQADNETIN ; 1200: YSNFLKAAVS ; NGIIKRRKDL ; HIHVSCKMLQ ; NTWVNTMYIT ; NNTVEIQEVQ ; 1250: YGNFDVNISF ; YTSSSFLYPV ; TSSPYYVDLD ; QNLYLQAEVL ; HSDTSLALFV ; 1300: DTCVASPHPN ; DFSSLTYDLI ; RSGCIRDETY ; QSYSSPSPRI ; TRFKFSSFHF ; 1350: LNRFPSVYLQ ; CKLVVCRAND ; VSSRCYRGCV ; VRSKRDVGSY ; QEKVDVVLGP ; 1400: IQLQSPSKEK ; RSLDLAVADV ; EKPASSQEVY ; PTAAIFGGVF ; LALVVAVAAF ; 1418: TLGRKTRTAR ; GQPPSTKM
Sequence Length	1418
String	Q8CIZ5
Sub Unit	Binds SFTPD and SPAR in a calcium-dependent manner (By similarity). Interacts with LGALS3.

Uniprot	Q8CIZ5
Gene Name	Dmbt1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:170568
Unigene	Rn.10107

Reference	1. "Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1." Bisgaard H.C., Holmskov U., Santoni-Rugiu E., Nagy P., Nielsen O., Ott P., Hage E., Dalhoff K., Rasmussen L.J., Tygstrup N. Am. J. Pathol.161:1187-1198(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY strain: Wistar. tissue: Liver. 2. "Pancrin a novel member of the scavenger receptor cysteine rich superfamily in the rat exocrine pancreas." Schmidt K., Kleene R.B., Schrader M. Submitted (2004-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) strain: Wistar. tissue: Pancreas. 3. "Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds." Li X.-J., Snyder S.H. J. Biol. Chem.270:17674-17679(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-1418 (ISOFORM 1);PROTEIN SEQUENCE OF 1058-1074;FUNCTION IN LIVER REGENERATION;FUNCTION IN REGULATION OF TASTE SENSATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY tissue: Tongue. 4. "Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3." Hikita C., Vijayakumar S., Takito J., Erdjument-Bromage H., Tempst P., Al-Awqati Q. J. Cell Biol.151:1235-1246(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LGALS3;FUNCTION

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