ELISA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1

Mfr.No.	E0794r
Alternative Names	Cyclin-dependent kinase 4 inhibitor A ; CDK4I ; p16-INK4a ; p16 ; p16-INK4 ; P16ink4a
Categories	Elisa
Function	Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Specificity	Natural and recombinant Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.156-10ng/ml
Entryname	CD2A1_RAT
Method Type	Sandwich
Platform	PF12796
Protein Name	Cyclin-dependent kinase inhibitor 2A, isoform 1
Sensitivity	0.09ng/mL
Sequence	50: MESSADRLAR ; AAALGREHEV ; RALLEAGASP ; NAPNTFGRTP ; IQVMMMGNVK ; 100: VAALLLSYGA ; DSNCEDPTTL ; SRPVHDAARE ; GFLDTLVVLH ; QAGARLDVRD ; 150: AWGRLPLDLA ; LERGHHDVVR ; YLRYLLSSAG ; NVSRVTDRHN ; FCSSTPRCLG ; 159: LRGQPPKQR
Sequence Length	159
String	Q9R0Z3
Sub Unit	Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

Reference	1. "Frequent aberrant methylation of p16INK4a in primary rat lung tumors." Swafford D.S., Middleton S.K., Palmisano W.A., Nikula K.J., Tesfaigzi J., Baylin S.B., Herman J.G., Belinsky S.A. Mol. Cell. Biol.17:1366-1374(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: Fischer 344/N. tissue: Lung. 2. Buckles L.K., Shull J.D. Submitted (2002-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: ACI/SegHsd. strain: Brown Norway/SsNHsd. strain: COP. tissue: Spleen.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801808	E0794r	96T	$796		Add to Cart