Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.
Specificity
Natural and recombinant Rat Cyclic AMP-dependent transcription factor ATF-4
Subcellular Location
Cytoplasm Cell membrane Nucleus Cytoplasm cytoskeleton centrosome Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Co-localizes with NEK6 in the centrosome.
Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the N-terminal region of CEP290 (By similarity). Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2. Forms a heterodimer with TXLNG in osteoblasts (By similarity). Interacts with NEK6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH GABBR1 AND GABBR2;SUBCELLULAR LOCATION