JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Cellular tumor antigen p53

SKU : BHE13808137

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0928r
Alternative Names	Tumor suppressor p53 ; P53
Categories	Elisa
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Specificity	Natural and recombinant Rat Cellular tumor antigen p53
Subcellular Location	Cytoplasm Nucleus Endoplasmic reticulum Interaction with BANP promotes nuclear localization.
Detection Range	0.156-10ng/mL
Entryname	P53_RAT
Method Type	Sandwich
Platform	PF00870
Protein Name	Cellular tumor antigen p53
Sensitivity	0.09ng/mL
Sequence	50: MEDSQSDMSI ; ELPLSQETFS ; CLWKLLPPDD ; ILPTTATGSP ; NSMEDLFLPQ ; 100: DVAELLEGPE ; EALQVSAPAA ; QEPGTEAPAP ; VAPASATPWP ; LSSSVPSQKT ; 150: YQGNYGFHLG ; FLQSGTAKSV ; MCTYSISLNK ; LFCQLAKTCP ; VQLWVTSTPP ; 200: PGTRVRAMAI ; YKKSQHMTEV ; VRRCPHHERC ; SDGDGLAPPQ ; HLIRVEGNPY ; 250: AEYLDDRQTF ; RHSVVVPYEP ; PEVGSDYTTI ; HYKYMCNSSC ; MGGMNRRPIL ; 300: TIITLEDSSG ; NLLGRDSFEV ; RVCACPGRDR ; RTEEENFRKK ; EEHCPELPPG ; 350: SAKRALPTST ; SSSPQQKKKP ; LDGEYFTLKI ; RGRERFEMFR ; ELNEALELKD ; 391: ARAAEESGDS ; RAHSSYPKTK ; KGQSTSRHKK ; PMIKKVGPDS ; D
Sequence Length	391
String	P10361
Sub Unit	Binds DNA as a homotetramer. Found in a complex with CABLES1 and TP73. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. The C-terminus interacts with TAF1, when TAF1 is part of the TFIID complex. Interacts with HIPK1, HIPK2, AXIN1, and P53DINP1. Part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with BANP. Interacts with ARMD10, E4F1, CDKN2AIP, NUAK1 and STK11/LKB1. Interacts with CHD8, leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction (By similarity). Interacts with HSP90AB1. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-380) with L3MBTL1 (By similarity). Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons.

Uniprot	P10361
Gene Name	Tp53
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24842
Unigene	Rn.54443

Reference	1. "Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein." Soussi T. Nucleic Acids Res.16:11384-11384(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Structure of the rat p53 tumor suppressor gene." Hulla J.E., Schneider R.P. Nucleic Acids Res.21:713-717(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53." Mathupala S.P., Heese C., Pedersen P.L. J. Biol. Chem.272:22776-22780(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Heart. tissue: Thymus. 5. "Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell." Sepehrnia B., Paz I.B., Dasgupta G., Momand J. J. Biol. Chem.271:15084-15090(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSP90AB1 tissue: Embryo. 6. "p53 opens the mitochondrial permeability transition pore to trigger necrosis." Vaseva A.V., Marchenko N.D., Ji K., Tsirka S.E., Holzmann S., Moll U.M. Cell149:1536-1548(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13808137	E0928r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.