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ELISA Kit for Rat Caspase-1

SKU : BHE13801761

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1592r
Alternative Names	Interleukin-1 beta convertase ; IL-1BC ; Interleukin-1 beta-converting enzyme ; ICE ; p45 ; Il1bc ; Il1bce
Categories	Elisa
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Specificity	Natural and recombinant Rat Caspase-1
Subcellular Location	Cytoplasm
Detection Range	78-5000pg/mL
Entryname	CASP1_RAT
Method Type	Sandwich
Platform	PF00619
Protein Name	Caspase-1
Sensitivity	41.5pg/mL
Sequence	50: MADKVLRAKR ; KQFINSVSVG ; TINGLLDELL ; EKRVLNQEEM ; DTIKLANITV ; 100: MEKARDLCDH ; VTKKGPRASQ ; MFITYICNED ; CYLAEILELQ ; SGPSAETVFV ; 150: TEDSKGGHPF ; SSETKEKLNK ; EGGAFPGPSG ; SLKFCPLEIA ; QKLWKENHSE ; 200: IYPIMKTPTR ; TRLALIICNT ; DFQHLSRRVG ; ADVDLREMKL ; LLQDLGYTVK ; 250: VKENLTALEM ; TKELKEFAAC ; PEHKTSDSTF ; LVFMSHGLQE ; GICGITYSNE ; 300: VADILKVDTI ; FQMMNTLKCP ; SLKDKPKVII ; IQACRGEKQG ; VVLLKDSVGN ; 350: SEEGFLTDAI ; FEDDGIKKAH ; IEKDFIAFCS ; STPDNVSWRH ; PVRGSLFIES ; 400: LIKHMKEYAW ; SCDLEDIFRK ; VRFSFEQPDS ; RLQMPTTERV ; TLTKRFYLFP ; 402: GH
Sequence Length	402
String	P43527
Sub Unit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed bya 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18.

Uniprot	P43527
Gene Name	Casp1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.37508

Reference	1. "Cloning, tissue expression and regulation of rat interleukin 1 beta converting enzyme." Keane K.M., Giegel D.A., Lipinski W.J., Callahan M.J., Shivers B.D. Cytokine7:105-110(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Spleen. 2. "Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle." Flaws J.A., Kugu K., Trbovich A.M., Desanti A., Tilly K.I., Hirshfield A.N., Tilly J.L. Endocrinology136:5042-5053(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 228-362 tissue: Ovary.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801761	E1592r	96T	$796		Add to Cart

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