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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat cAMP-dependent protein kinase catalytic subunit beta

SKU : BHE13806153

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1987r
Alternative Names	Pkacb
Categories	Elisa
Function	Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Specificity	Natural and recombinant Rat cAMP-dependent protein kinase catalytic subunit beta
Subcellular Location	Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
Detection Range	0.312-20ng/mL
Entryname	KAPCB_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	cAMP-dependent protein kinase catalytic subunit beta
Sensitivity	0.192ng/mL
Sequence	50: MGNTAIAKKG ; SEVESVKEFL ; AKAKEDFLRK ; WENPPPSNAG ; LEDFERKKTL ; 100: GTGSFGRVML ; VKHKATEQYY ; AMKILDKQKV ; VKLKQIEHTL ; NEKRILQAVE ; 150: FPFLVRLEYS ; FKDNSNLYMV ; MEYVPGGEMF ; SHLRRIGRFS ; EPHARFYAAQ ; 200: IVLTFEYLHS ; LDLIYRDLKP ; ENLLIDHQGY ; IQVTDFGFAK ; RVKGRTWTLC ; 250: GTPEYLAPEI ; ILSKGYNKAV ; DWWALGVLIY ; EMAAGYPPFF ; ADQPIQIYEK ; 300: IVSGKVRFPS ; HFSSDLKDLL ; RNLLQVDLTK ; RFGNLKNGVS ; DIKTHKWFAT ; 350: TDWIAIYQRK ; VEAPFIPKFR ; GSGDTSNFDD ; YEEEEIRVSI ; TEKCGKEFCE ; 351: F
Sequence Length	351
String	P68182
Sub Unit	A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.

Uniprot	P68182
Gene Name	Prkacb
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:293508
Unigene	Rn.202491

Reference	1. "Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells." Shuntoh H., Sakamoto N., Matsuyama S., Saitoh M., Tanaka C. Biochim. Biophys. Acta1131:175-180(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry." Jedrzejewski P.T., Girod A., Tholey A., Koenig N., Thullner S., Kinzel V., Bossemeyer D. Protein Sci.7:457-469(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-8;DEAMIDATION AT ASN-3

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806153	E1987r	96T	$796		Add to Cart

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