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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat cAMP-dependent protein kinase catalytic subunit alpha

SKU : BHE13806207

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1918r
Categories	Elisa
Function	Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Specificity	Natural and recombinant Rat cAMP-dependent protein kinase catalytic subunit alpha
Subcellular Location	Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
Detection Range	0.312-20ng/mL
Entryname	KAPCA_RAT
Method Type	Sandwich
Platform	PF00069
Protein Name	cAMP-dependent protein kinase catalytic subunit alpha
Sensitivity	0.162ng/mL
Sequence	50: MGNAAAAKKG ; SEQESVKEFL ; AKAKEDFLKK ; WEDPSQNTAQ ; LDHFDRIKTL ; 100: GTGSFGRVML ; VKHKESGNHY ; AMKILDKQKV ; VKLKQIEHTL ; NEKRILQAVN ; 150: FPFLVKLEFS ; FKDNSNLYMV ; MEYVPGGEMF ; SHLRRIGRFS ; EPHARFYAAQ ; 200: IVLTFEYLHS ; LDLIYRDLKP ; ENLLIDQQGY ; IQVTDFGFAK ; RVKGRTWTLC ; 250: GTPEYLAPEI ; ILSKGYNKAV ; DWWALGVLIY ; EMAAGYPPFF ; ADQPIQIYEK ; 300: IVSGKVRFPS ; HFSSDLKDLL ; RNLLQVDLTK ; RFGNLKNGVN ; DIKNHKWFAT ; 350: TDWIAIYQRK ; VEAPFIPKFK ; GPGDTSNFDD ; YEEEEIRVSI ; NEKCGKEFTE ; 351: F
Sequence Length	351
String	P27791
Sub Unit	A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.

Uniprot	P27791
Gene Name	Prkaca
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.20

Reference	1. "Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts." Wiemann S., Voss H., Kinzel V., Pyerin W. Biochim. Biophys. Acta1089:254-256(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY 2. "A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry." Jedrzejewski P.T., Girod A., Tholey A., Koenig N., Thullner S., Kinzel V., Bossemeyer D. Protein Sci.7:457-469(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-8 (ISOFORM 1);MYRISTOYLATION AT GLY-2;DEAMIDATION AT ASN-3 3. "Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus." Ullas K.S., Rao M.R.S. J. Biol. Chem.278:52673-52680(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-313 (ISOFORM 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE strain: Wistar. 4. "Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep." Datta S., Desarnaud F. J. Neurosci.30:12263-12273(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RAPID EYE MOVEMENT SLEEP 5. "RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A." Su W., Liu X. J. Mol. Endocrinol.50:305-318(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB13

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806207	E1918r	96T	$796		Add to Cart

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