ELISA Kit for Rat BH3-interacting domain death agonist

Mfr.No.	E0629r
Alternative Names	p22 BID ; BID
Categories	Elisa
Function	Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.
Specificity	Natural and recombinant Rat BH3-interacting domain death agonist
Subcellular Location	Cytoplasm Mitochondrion membrane When uncleaved, it is predominantly cytoplasmic. p15 BID translocates to mitochondria as an integral membrane protein. p13 and p22 BID are associated with the mitochondrial membrane.
Detection Range	0.312-20ng/mL
Entryname	BID_RAT
Method Type	Sandwich
Platform	PF06393
Protein Name	BH3-interacting domain death agonist
Sensitivity	0.157ng/mL
Sequence	50: MDSEVSNGSG ; LGAEHITNLL ; VFGFLRNNDR ; DFHQELEVLG ; QELPVQVYLE ; 100: GDREDELQTD ; GSRASRSFYH ; GRIEPDSESQ ; DEVIHNIARH ; LAQAGDELDH ; 150: SIQPTLVRQL ; AAQFMNGSLS ; EEDKRNCLAK ; ALDEVKTSFP ; RDMENDKAML ; 196: IMTMLLAKKV ; ASHAPSLLRD ; VFRTTVNFIN ; QNLFSYVRDL ; VRNEMD
Sequence Length	196
String	Q9JLT6
Sub Unit	Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH.

Reference	1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation." Itoh T., Itoh A., Pleasure D. J. Neurochem.85:1500-1512(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. 2. "Cloning of rat apoptotic death agonist (BID) and its different expression in ischemia and normal rat brain." Chen D., Cao G., Chen J. Submitted (1999-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley.

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