ELISA Kit for Rat Bcl2-associated agonist of cell death

Mfr.No.	E15040r
Alternative Names	Bcl-2-binding component 6 ; Bcl-xL/Bcl-2-associated death promoter ; Bcl2 antagonist of cell death
Categories	Elisa
Function	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Specificity	Natural and recombinant Rat Bcl2-associated agonist of cell death
Subcellular Location	Mitochondrion outer membrane Cytoplasm Upon phosphorylation, locates to the cytoplasm.
Entryname	BAD_RAT
Method Type	Sandwich
Platform	PF10514
Protein Name	Bcl2-associated agonist of cell death
Sequence	50: MGTPKQPSLA ; PAHALGLRKS ; DPGIRSLGSD ; AGGRRWRPAA ; QSMFQIPEFE ; 100: PSEQEDASTT ; DRGLGPSLTE ; DQPGPYLAPG ; LLGSIVQQQP ; GQAANNSHHG ; 150: GAGTMETRSR ; HSSYPAGTEE ; DEGMEEELSP ; FRGRSRSAPP ; NLWAAQRYGR ; 200: ELRRMSDEFE ; GSFKGLPRPK ; SAGTATQMRQ ; SASWTRIIQS ; WWDRNLGKGG ; 205: STPSQ
Sequence Length	205
String	O35147
Sub Unit	Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10. The Ser-113/Ser-137 phosphorylated form binds 14-3-3 proteins. Interacts with PIM3.

Reference	1. "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11." Hsu S.Y., Kaipia A., Zhu L., Hsueh A.J.W. Mol. Endocrinol.11:1858-1867(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF SER-113 AND SER-137 tissue: Ovary. 2. "Cloning and expression of the programmed cell death regulator BAD in the rat brain." D'Agata V., Magro G., Travali S., Musco S., Cavallaro S. Neurosci. Lett.243:137-140(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 3. "Functional characterization of two splice variants of rat BAD and their interaction with Bcl-w in sympathetic neurons." Hamner S., Arumae U., Yu L.-Y., Sun Y.-F., Saarma M., Lindholm D. Mol. Cell. Neurosci.17:97-106(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA) tissue: Brain.

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BHE13801508	E15040r	96T	$796		Add to Cart