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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Apoptosis regulator Bcl-2

SKU : BHE13801467

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0778r
Alternative Names	Bcl-2
Categories	Elisa
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Specificity	Natural and recombinant Rat Apoptosis regulator Bcl-2
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Detection Range	1.56-100ng/mL
Entryname	BCL2_RAT
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator Bcl-2
Sensitivity	0.85ng/mL
Sequence	50: MAQAGRTGYD ; NREIVMKYIH ; YKLSQRGYEW ; DTGDEDSAPL ; RAAPTPGIFS ; 100: FQPESNRTPA ; VHRDTAARTS ; PLRPLVANAG ; PALSPVPPVV ; HLTLRRAGDD ; 150: FSRRYRRDFA ; EMSSQLHLTP ; FTARGRFATV ; VEELFRDGVN ; WGRIVAFFEF ; 200: GGVMCVESVN ; REMSPLVDNI ; ALWMTEYLNR ; HLHTWIQDNG ; GWDAFVELYG ; 236: PSMRPLFDFS ; WLSLKTLLSL ; ALVGACITLG ; AYLGHK
Sequence Length	236
String	P49950
Sub Unit	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, FKBP8, MRPL41, RAF-1, TP53BP2. Interacts with BAG1 in an ATP-dependent manner.

Uniprot	P49950
Gene Name	Bcl2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24224
Unigene	Rn.9996

Reference	1. "Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein." Sato T., Irie S., Krajewski S., Reed J.C. Gene140:291-292(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels." Tilly J.L., Tilly K.I., Kenton M.L., Johnson A.L. Endocrinology136:232-241(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Ovary. 3. "bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain." Castren E., Ohga Y., Berzaghi M.P., Tzimagiorgis G., Thoenen H., Lindholm D. Neuroscience61:165-177(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-172 4. "Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect." Eliseev R.A., Malecki J., Lester T., Zhang Y., Humphrey J., Gunter T.E. J. Biol. Chem.284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIF

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801467	E0778r	96T	$796		Add to Cart

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