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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Amyloid beta A4 protein

SKU : BHE13800484

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0946r
Alternative Names	ABPP ; APP ; Alzheimer disease amyloid A4 protein homolog ; Amyloid precursor protein ; Amyloidogenic glycoprotein ; AG ; Beta-amyloid precursor protein
Categories	Elisa
Function	N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Specificity	Natural and recombinant Rat Amyloid beta A4 protein
Subcellular Location	Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65) (By similarity). Beta-APP42 associates with FPRL1 at the cell surface and the complex is then rapidly internalized (By similarity). APP sorts to the basolateral surface in epithelial cells (By similarity). During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body.
Detection Range	0.312-20ng/mL
Entryname	A4_RAT
Method Type	Sandwich
Platform	PF10515
Protein Name	Amyloid beta A4 protein
Sensitivity	0.164ng/mL
Sequence	50: MLPSLALLLL ; AAWTVRALEV ; PTDGNAGLLA ; EPQIAMFCGK ; LNMHMNVQNG ; 100: KWESDPSGTK ; TCIGTKEGIL ; QYCQEVYPEL ; QITNVVEANQ ; PVTIQNWCKR ; 150: GRKQCKTHTH ; IVIPYRCLVG ; EFVSDALLVP ; DKCKFLHQER ; MDVCETHLHW ; 200: HTVAKETCSE ; KSTNLHDYGM ; LLPCGIDKFR ; GVEFVCCPLA ; EESDSIDSAD ; 250: AEEDDSDVWW ; GGADTDYADG ; GEDKVVEVAE ; EEEVADVEEE ; EAEDDEDVED ; 300: GDEVEEEAEE ; PYEEATERTT ; SIATTTTTTT ; ESVEEVVREV ; CSEQAETGPC ; 350: RAMISRWYFD ; VTEGKCAPFF ; YGGCGGNRNN ; FDTEEYCMAV ; CGSVSSQSLL ; 400: KTTSEPLPQD ; PVKLPTTAAS ; TPDAVDKYLE ; TPGDENEHAH ; FQKAKERLEA ; 450: KHRERMSQVM ; REWEEAERQA ; KNLPKADKKA ; VIQHFQEKVE ; SLEQEAANER ; 500: QQLVETHMAR ; VEAMLNDRRR ; LALENYITAL ; QAVPPRPHHV ; FNMLKKYVRA ; 550: EQKDRQHTLK ; HFEHVRMVDP ; KKAAQIRSQV ; MTHLRVIYER ; MNQSLSLLYN ; 600: VPAVAEEIQD ; EVDELLQKEQ ; NYSDDVLANM ; ISEPRISYGN ; DALMPSLTET ; 650: KTTVELLPVN ; GEFSLDDLQP ; WHPFGVDSVP ; ANTENEVEPV ; DARPAADRGL ; 700: TTRPGSGLTN ; IKTEEISEVK ; MDAEFGHDSG ; FEVRHQKLVF ; FAEDVGSNKG ; 750: AIIGLMVGGV ; VIATVIVITL ; VMLKKKQYTS ; IHHGVVEVDA ; AVTPEERHLS ; 770: KMQQNGYENP ; TYKFFEQMQN ;
Sequence Length	770
String	P08592
Sub Unit	Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) (By similarity) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons (By similarity). Beta-amyloid associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Uniprot	P08592
Gene Name	App
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:54226
Unigene	Rn.2104

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800484	E0946r	96T	$796		Add to Cart

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