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ELISA Kit for Rat 4F2 cell-surface antigen heavy chain

SKU : BHE13800305

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2005r
Alternative Names	Solute carrier family 3 member 2 ; CD98
Categories	Elisa
Function	Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Specificity	Natural and recombinant Rat 4F2 cell-surface antigen heavy chain
Subcellular Location	Apical cell membrane Single-pass type II membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localized to the plasma membrane when associated with SLC7A5 or SLC7A8 (By similarity). Localized to the placental apical membrane (By similarity). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
Detection Range	0.312-20ng/mL
Entryname	4F2_RAT
Method Type	Sandwich
Platform	PF00128
Protein Name	4F2 cell-surface antigen heavy chain
Sensitivity	0.174ng/mL
Sequence	50: MSQDTEVDMK ; DVELNELEPE ; KQPMNAADGA ; AAGEKNGLVK ; IKVAEDEAEA ; 100: GVKFTGLSKE ; ELLKVAGSPG ; WVRTRWALLL ; LFWLGWLGML ; AGAVVIIVRA ; 150: PRCRELPVQR ; WWHKGALYRI ; GDLQAFVGPE ; ARGIAGLKNH ; LEYLSTLKVK ; 200: GLVLGPIHKN ; QKDEVNETDL ; KQIDPDLGSQ ; EDFKDLLQSA ; KKKSIHIILD ; 250: LTPNYKGQNA ; WFLPPQADIV ; ATKMKEALSS ; WLQDGVDGFQ ; VRDVGKLANA ; 300: SLYLAEWQNI ; TKNFSEDRLL ; IAGTASSDLQ ; QIVNILESTS ; DLLLTSSYLS ; 350: QPVFTGEHAE ; LLVIKYLNAT ; GSRWCSWSVS ; QAGLLTSFIP ; AQFLRLYQLL ; 400: LFTLPGTPVF ; SYGDELGLQA ; VALPGQPMEA ; PFMLWNESSN ; SQTSSPVSLN ; 450: MTVKGQNEDP ; GSLLTQFRRL ; SDLRGKERSL ; LHGDFDALSS ; SSGLFSYVRH ; 500: WDQNERYLVV ; LNFQDVGLSA ; RVGASNLPAG ; ISLPASANLL ; LSTDSTRLSR ; 527: EEGTSLSLEN ; LSLNPYEGLL ; LQFPFVA
Sequence Length	527
String	Q794F9
Sub Unit	Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1 (By similarity). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1.

Uniprot	Q794F9
Gene Name	Slc3a2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:50567
Unigene	Rn.5801

Reference	1. "Cloning and functional expression of a cDNA from rat jejunal epithelium encoding a protein (4F2hc) with system y+L amino acid transport activity." Yao S.Y.M., Muzyka W.R., Elliott J.F., Cheeseman C.I., Young J.D. Biochem. J.330:745-752(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION strain: Sprague-Dawley. tissue: Jejunal epithelium. 2. "Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)." Kanai Y., Segawa H., Miyamoto K., Uchino H., Takeda E., Endou H. J. Biol. Chem.273:23629-23632(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBUNIT tissue: Glial tumor. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 4. "Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity." Segawa H., Fukasawa Y., Miyamoto K., Takeda E., Endou H., Kanai Y. J. Biol. Chem.274:19745-19751(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;TISSUE SPECIFICITY 5. "Expression of a system L neutral amino acid transporter at the blood-brain barrier." Matsuo H., Tsukada S., Nakata T., Chairoungdua A., Kim D.K., Cha S.H., Inatomi J., Yorifuji H., Fukuda J., Endou H., Kanai Y. NeuroReport11:3507-3511(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION 6. "Transcriptional regulation of the LAT-1/CD98 light chain." Padbury J.F., Diah S.K., McGonnigal B., Miller C., Fugere C., Kuzniar M., Thompson N.L. Biochem. Biophys. Res. Commun.318:529-534(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION 7. "L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier." Tomi M., Mori M., Tachikawa M., Katayama K., Terasaki T., Hosoya K. Invest. Ophthalmol. Vis. Sci.46:2522-2530(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

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