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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat 14-3-3 protein zeta/delta

SKU : BHE13800208

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14294r
Alternative Names	Mitochondrial import stimulation factor S1 subunit ; Protein kinase C inhibitor protein 1 ; KCIP-1 ; Msfs1
Categories	Elisa
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Specificity	Natural and recombinant Rat 14-3-3 protein zeta/delta
Subcellular Location	Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
Detection Range	31.2-2000pg/mL
Entryname	1433Z_RAT
Method Type	Sandwich
Platform	PF00244
Protein Name	14-3-3 protein zeta/delta
Sensitivity	15.68pg/mL
Sequence	50: MDKNELVQKA ; KLAEQAERYD ; DMAACMKSVT ; EQGAELSNEE ; RNLLSVAYKN ; 100: VVGARRSSWR ; VVSSIEQKTE ; GAEKKQQMAR ; EYREKIETEL ; RDICNDVLSL ; 150: LEKFLIPNAS ; QPESKVFYLK ; MKGDYYRYLA ; EVAAGDDKKG ; IVDQSQQAYQ ; 200: EAFEISKKEM ; QPTHPIRLGL ; ALNFSVFYYE ; ILNSPEKACS ; LAKTAFDEAI ; 245: AELDTLSEES ; YKDSTLIMQL ; LRDNLTLWTS ; DTQGDEAEAG ; EGGEN
Sequence Length	245
String	P63102
Sub Unit	Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 and SAMSN1 (By similarity). Interacts with BSPRY. Interacts with BCL2L11.

Uniprot	P63102
Gene Name	Ywhaz
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25578
Unigene	Rn.1292

Reference	1. "Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain." Watanabe M., Isobe T., Ichimura T., Kuwano R., Takahashi Y., Kondo H., Inoue Y. Brain Res. Mol. Brain Res.25:113-121(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Wistar. tissue: Brain. 2. "A gene variation of 14-3-3 zeta isoform in rat hippocampus." Murakami K., Situ S.Y., Eshete F. Gene179:245-249(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Hippocampus. 3. "cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol." Alam R., Hachiya N., Sakaguchi M., Shun-Ichiro K., Iwanaga S., Kitajima M., Mihara K., Omura T. J. Biochem.116:416-425(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. tissue: Lung. 5. Bienvenut W.V., von Kriegsheim A., Kolch W. Submitted (2009-06) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-9; 12-49; 61-68; 92-115; 128-157 AND 213-222;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY tissue: Fibroblast. tissue: Pheochromocytoma. 6. Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U., Lubec S. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 12-55; 57-68; 84-115; 121-167; 159-187 AND 194-245;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Brain. tissue: Hippocampus. tissue: Spinal cord. 7. "Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis." Ganguly S., Gastel J.A., Weller J.L., Schwartz C., Jaffe H., Namboodiri M.A., Coon S.L., Hickman A.B., Rollag M., Obsil T., Beauverger P., Ferry G., Boutin J.A., Klein D.C. Proc. Natl. Acad. Sci. U.S.A.98:8083-8088(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-41; 61-68 AND 128-139;INTERACTION WITH AANAT;IDENTIFICATION BY MASS SPECTROMETRY 8. "Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins." Roseboom P.H., Weller J.L., Babila T., Aitken A., Sellers L.A., Moffet J.R., Namboodiri M.A., Klein D.C. DNA Cell Biol.13:629-640(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 58-245 strain: Sprague-Dawley. tissue: Pineal gland. 9. "Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins." Birkenfeld J., Kartmann B., Anliker B., Ono K., Schloetcke B., Betz H., Roth D. Biochem. Biophys. Res. Commun.302:526-533(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH BSPRY 10. "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection." Thompson S., Pearson A.N., Ashley M.D., Jessick V., Murphy B.M., Gafken P., Henshall D.C., Morris K.T., Simon R.P., Meller R. J. Biol. Chem.286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2L11

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