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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Tyrosine-protein kinase SYK

SKU : BHE13806600

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1520p
Alternative Names	Spleen tyrosine kinase
Categories	Elisa
Function	Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-341 and Tyr-345. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Likewise, mediates responses to ITGB2 signaling and plays an important role in the regulation of down-stream signaling cascades. Phosphorylates USP25 and regulates its intracellular levels.
Specificity	Natural and recombinant Pig Tyrosine-protein kinase SYK
Subcellular Location	40 kDa tyrosine-protein kinase SYK Cytoplasm
Entryname	KSYK_PIG
Platform	PF07714
Protein Name	Tyrosine-protein kinase SYK
Sequence	50: MADSANHLPF ; FFGQITREEA ; EDYLVQGGMS ; DGLYLLRQSR ; NYLGGFALSV ; 100: AYDRKAHHYT ; IERELNGTYA ; ISGGRTHGSP ; AELCHYHSQE ; LDGLVCLLKN ; 150: PFNRPPGVQP ; KTGPFEDLKE ; NLIREYVKQT ; WNLQGQALEQ ; AIISQKPQLE ; 200: KLIATTAHEK ; MPWFHGKISR ; DESEQIVLIG ; SKTNGKFLIR ; ARDNGSYALG ; 250: LLHEGKVLHY ; RIDKDKTGKL ; SIPGGKNFDT ; LWQLVEHYSY ; KSDGLLRVLT ; 300: VPCQKIGGQT ; GNDSFRPQLP ; SAHPATWSAG ; GIISRIKSYS ; FPKPGHRKAS ; 350: SPQGNRPESL ; VSYNPYESDR ; GPWANEREAQ ; REALPMDTEV ; YESPYADPEE ; 400: IRPKEVYLDR ; KLLTLEDKEL ; GSGNFGTVKK ; GYYQMKKVVK ; TVAVKILKNE ; 450: ANDPALKDEL ; LAEANVMQQL ; DNPYIVRMIG ; ICEAESWMLV ; MEMAELGPLN ; 500: KYLQQNRHVK ; DKNIIELVHQ ; VSMGMKYLEE ; CNFVHRDLAA ; RNVLLVTQHY ; 550: AKISDFGLSK ; ALRADENYYK ; AQTHGKWPVK ; WYAPECINYY ; KFSSKSDVWS ; 600: FGVLMWEAFS ; YGQKPYRGMK ; GSEVSAMLEK ; GERMGCPPGC ; PREMYELMTL ; 628: CWTYDVENRP ; GFVAVELRLR ; NYYYDVVN
Sequence Length	628
String	Q00655
Sub Unit	Interacts with RHOH, GAB2 and with NFAM1 (phosphorylated form). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation. Interacts with ITGB2 and FGR. Interacts (phosphorylated form) with SLA; the interaction may link it to CBL, leading to its destruction. Interacts with FCRL3. Interacts (via the second SH2 domain) with USP25 (via C-terminus). Interacts with YWHAG/1433-gamma, which attenuates BCR-induced membrane translocation and activation.

Uniprot	Q00655
Gene Name	SYK
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:100125540
Unigene	Ssc.55112

Reference	1. "Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis." Taniguchi T., Kobayashi T., Kondo J., Takahashi K., Nakamura H., Suzuki J., Nagai K., Yamada T., Nakamura S., Yamamura H. J. Biol. Chem.266:15790-15796(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 313-333; 346-354 AND 369-379 tissue: Spleen. 2. "Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling." Kurosaki T., Takata M., Yamanashi Y., Inazu T., Taniguchi T., Yamamoto T., Yamamura H. J. Exp. Med.179:1725-1729(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY LYN;INTERACTION WITH LYN;AUTOPHOSPHORYLATION 3. "Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product." Deckert M., Tartare-Deckert S., Couture C., Mustelin T., Altman A. Immunity5:591-604(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REGULATION;INTERACTION WITH VAV1;MUTAGENESIS OF TYR-341 AND TYR-345;PHOSPHORYLATION AT TYR-341 4. "BLNK mediates Syk-dependent Btk activation." Baba Y., Hashimoto S., Matsushita M., Watanabe D., Kishimoto T., Kurosaki T., Tsukada S. Proc. Natl. Acad. Sci. U.S.A.98:2582-2586(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BTK 5. "Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase." Maeno K., Sada K., Kyo S., Miah S.M., Kawauchi-Kamata K., Qu X., Shi Y., Yamamura H. J. Biol. Chem.278:24912-24920(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SH3BP2;MUTAGENESIS OF LYS-395;ENZYME REGULATION 6. "Interdomain A is crucial for ITAM-dependent and -independent regulation of Syk." Adachi T., Wienands J., Tsubata T., Kurosaki T. Biochem. Biophys. Res. Commun.364:111-117(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806600	E1520p	96T	$900		Add to Cart

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