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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Signal transducer and activator of transcription 1

SKU : BHE13809887

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1740p
Categories	Elisa
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Specificity	Natural and recombinant Pig Signal transducer and activator of transcription 1
Subcellular Location	Cytoplasm Nucleus Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1; FGFR2; FGFR3 or FGFR4.
Entryname	STAT1_PIG
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 1
Sequence	50: MSQWYELQQL ; DSKFLEQVHQ ; LYDDSFPMEI ; RQYLAQWLEN ; QDWEHAANDV ; 100: SFATIRFHDL ; LSQLDDQYSR ; FSLENNFLLQ ; HNIRKSKRNL ; QDNFQEDPIQ ; 150: MSMIICNCLK ; EERKILENAQ ; RFNQTQSGNI ; QSTVMLDKHK ; ELDSKVRNVK ; 200: DKVMCIEHEI ; KTLEDLQDEY ; DFKCKTLQNR ; EHDTNGVAKN ; DQKQEQMLLQ ; 250: KMYLMLDNKR ; KEVVHKIIEL ; LNVTELTQKA ; LINDELVEWK ; RRQQSACIGG ; 300: PPNACLDQLQ ; NWFTIVAESL ; QQVRQQLKKL ; EELEQKYTYE ; HDPITKNKQA ; 350: LWDRTFSLFQ ; QLIQSSFVVE ; RQPCMPTHPQ ; RPLVLKTGVQ ; FTVKLRLLVK ; 400: LQKLNYNLKV ; KVLFDKDVSE ; RNTVKGFRKF ; NILGTHTKVM ; NMEESTNGSL ; 450: AAEFRHLQLK ; EQKNAGARTN ; EGPLIVTEEL ; HSLSFETQLC ; QPGLVIDLET ; 500: TSLPVVVISN ; VSQLPSGWAS ; ILWYNMLVAE ; PRNLSFFLNP ; PCARWSQLSE ; 550: VLSWQFSSVT ; KRGLNVDQLN ; MLGEKLLGPT ; AGPDGLIPWT ; RFCKENINDK ; 600: NFPFWLWIES ; ILELIKKHLL ; SLWNDGCIVG ; FISKERERAL ; LKDQQPGTFL ; 650: LRFSESCREG ; AITFTWVERS ; QNGGEPYFHA ; VEPYTKKELS ; AVTFPDIIRN ; 700: YKVMAAENIP ; ENPLKYLYPN ; IDKDHAFGKY ; YSRPKEAPEP ; MELDGPKGTG ; 750: YIKTELISVS ; EVHPSRLQTT ; DNLLPMSPEE ; FDEVSRMVGP ; VEFDVTWNKF ; 757: SGTMNLD
Sequence Length	757
Sub Unit	In response to IFN alpha/beta, three subunits (STAT1-alpha, STAT1-beta, STAT2) of ISGF3, become phosphorylated on tyrosine, migrate into the nucleus, and assemble into a complex together with ISGF3 gamma (p48), a DNA-binding protein that specifically binds to the IFN-stimulated response element. In response to IFN gamma, STAT1 forms homodimers, that also translocate into the nucleus to activate IFN gamma-responsive genes. Interacts with NMI. Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation. Interacts with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its target gene. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2.

Uniprot	Q764M5
Gene Name	STAT1
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:396655
Unigene	Ssc.42622

Reference	1. "PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries." Uenishi H., Eguchi T., Suzuki K., Sawazaki T., Toki D., Shinkai H., Okumura N., Hamasima N., Awata T. Nucleic Acids Res.32:D484-D488(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809887	E1740p	96T	$900		Add to Cart

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