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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Prelamin-A/C

SKU : BHE13806467

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11923p
Categories	Elisa
Function	Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Specificity	Natural and recombinant Pig Prelamin-A/C
Subcellular Location	Nucleus Nucleus envelope Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.
Entryname	LMNA_PIG
Platform	PF00038
Protein Name	Prelamin-A/C
Sequence	50: METPSQRRAT ; RSGAQASSTP ; LSPTRITRLQ ; EKEDLQELND ; RLAVYIDRVR ; 100: SLETENAGLR ; LRITESEEVV ; SREVSGIKSA ; YEAELGDARK ; TLDSVAKERA ; 150: RLQLELSKVR ; EEFKELKARN ; TKKEGDLMAA ; QARLKDLEAL ; LNSKEAALST ; 200: ALSEKRTLEG ; ELHDLRGQVA ; KLEAALGEAK ; KQLQDEMLRR ; VDAENRLQTL ; 250: KEELDFQKNI ; YSEELRETKR ; RHETRLVEID ; NGKQREFESR ; LADALQDLRA ; 300: QHEDQVEQYK ; KELEKTYSAK ; LDNARQSAER ; NSNLVGAAHE ; ELQQSRIRID ; 350: SLSAQLSQLQ ; KQLAAKEAKL ; RDLEDSLARE ; RDTSRRLLAD ; KEREMAEMRA ; 400: RMQQQLDEYQ ; ELLDIKLALD ; MEIHAYRKLL ; EGEEERLRLS ; PSPTSQRSRG ; 450: RASSHSSQTQ ; SGGSVTKKRK ; LESSESRSSF ; SQHARTSGRV ; AVEEVDEEGK ; 500: FVRLRNKSNE ; DQSMGNWQIK ; RQNGDDPLLT ; YRFPPKFTLK ; AGQVVTIWAA ; 550: GAGATHSPPA ; DLVWKSQNTW ; GCGNSLRTAL ; INSTGEEVAM ; RKLVRSVTMI ; 600: EDDEDEDGDD ; LLHHHHGSHG ; SSSGDPAEYN ; LRSRTVLCGT ; CGQPADKASA ; 650: SSSGAQVGGS ; ISSGSSASSV ; TVTRSYRSVG ; GSGGGSFGDN ; LVTRSYLLGN ; 664: SRPRTQSPQN ; CSIM
Sequence Length	664
String	Q3ZD69
Sub Unit	Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Interacts with SREBF1, SREBF2, SUN1, SUN2 and TMEM43. Proteolytically processed isoform A interacts with NARF. Prelamin-A/C interacts with EMD. Interacts with MLIP; may regulate MLIP localization to the nucleus envelope.

Uniprot	Q3ZD69
Gene Name	LMNA
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:100126859
Unigene	Ssc.944

Reference	1. "Characterization of the porcine LMNA gene exhibiting developmentally regulated expression." Jacobsen M., Horn P., Bendixen C. Submitted (2005-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806467	E11923p	96T	$900		Add to Cart

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