Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
Specificity
Natural and recombinant Pig Myeloid differentiation primary response protein MyD88
Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL1RL1. Interacts with IL18R1. Interacts with BMX and IRF7 (By similarity). Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist (By similarity). Interacts with FLII (By similarity). LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding.
"Molecular cloning and tissue-specific expression of porcine myeloid differentiation primary response gene 88 (MYD88)." Li Q., Li X., Zhu L., Chen L., Li M., Wu X. Submitted (2006-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
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4.
"Molecular cloning and sequence analysis of porcine myeloid differentiation primary response gene 88 (MYD88)." He Y., Wang D., Jiang Y., Fang L., Chen H., Xiao S. Submitted (2007-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]