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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Interferon regulatory factor 3

SKU : BHE13804564

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1491p
Categories	Elisa
Function	Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
Specificity	Natural and recombinant Pig Interferon regulatory factor 3
Subcellular Location	Cytoplasm Nucleus Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.
Entryname	IRF3_PIG
Platform	PF00605
Protein Name	Interferon regulatory factor 3
Sequence	50: MGTQKPRILP ; WLISQLNQGQ ; LEGVAWLDEG ; HTRFRIPWKH ; GLRQDAQQED ; 100: FGIFQAWAEA ; SGAYTPGKDK ; PDLPTWKRNF ; RSALNRKEAL ; RLAEDHSKDP ; 150: HDPHKIYEFV ; TSGVGDFPEP ; DTSLDLSGRY ; STSDTHEDSL ; DKLLSGMDLA ; 200: SDAGPQSLTL ; ALEQPPQLSL ; SPSVDAPASC ; PNLGVRENPL ; KQLLANDDEW ; 250: EFQVTVFYRG ; CQVFQQTVCS ; PGGLRLVGSE ; AEDGTLAGQP ; VRLPDPAASL ; 300: TDRGVADYVR ; RVLSCLGGGL ; ALWRAGQWLW ; AQRLGHCHVY ; WAMGEELIPD ; 350: SGHKPDGEVP ; KDREGGVFDL ; GPFIEDLIAF ; IEGSRRSPRY ; TLWFCMGQSW ; 400: PQDEPWVKRL ; VMVKVVPMCL ; RALVDMARDG ; GASSLENTVD ; LHISNSHPLS ; 419: LTSDQYKACL ; RDLVEDMDF
Sequence Length	419
String	Q764M6
Sub Unit	Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Uniprot	Q764M6
Gene Name	IRF3
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:396656
Unigene	Ssc.79511

Reference	1. "PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries." Uenishi H., Eguchi T., Suzuki K., Sawazaki T., Toki D., Shinkai H., Okumura N., Hamasima N., Awata T. Nucleic Acids Res.32:D484-D488(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804564	E1491p	96T	$900		Add to Cart

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