The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Specificity
Natural and recombinant Pig Growth hormone receptor
Subcellular Location
Cell membrane Single-pass type I membrane protein On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.
On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain (By similarity). Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;STAT5 ACTIVATION;MUTAGENESIS OF TYR-332; TYR-337; TYR-390; TYR-487; TYR-534; TYR-566; TYR-595 AND TYR-627
Reviews of ELISA Kit for Pig Growth hormone receptor