ELISA Kit for Pig Alpha-endosulfine

Mfr.No.	E15255p
Alternative Names	ARPP-19e
Categories	Elisa
Function	Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Specificity	Natural and recombinant Pig Alpha-endosulfine
Subcellular Location	Cytoplasm
Entryname	ENSA_PIG
Platform	PF04667
Protein Name	Alpha-endosulfine
Sequence	50: MSQKQEEENP ; AEETGEEKQD ; TQEKEGILPE ; KAEEAKLKAK ; YPSLGQKPGG ; 100: SDFLMKRLQK ; GQKYFDSGDY ; NMAKAKMKNK ; QLPSAGPDKN ; LVTGDHIPTP ; 121: QDLPQRKSSL ; VTSKLAGGQV ; E
Sequence Length	121
Sub Unit	Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.

Reference	1. "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties." Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D. Proc. Natl. Acad. Sci. U.S.A.95:8387-8391(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Endosulfine, endogenous ligand for the sulphonylurea receptor: isolation from porcine brain and partial structural determination of the alpha form." Virsolvy-Vergine A., Salazar G., Sillard R., Denoroy L., Mutt V., Bataille D. Diabetologia39:135-141(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-36; 39-57; 59-74 AND 81-106;MASS SPECTROMETRY;CHARACTERIZATION tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803904	E15255p	96T	$900		Add to Cart