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ELISA Kit for Mouse Wilms tumor protein homolog

SKU : BHE13811421

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11563m
Alternative Names	Wt-1
Categories	Elisa
Function	Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Specificity	Natural and recombinant Mouse Wilms tumor protein homolog
Subcellular Location	Nucleus Nucleus nucleolus Cytoplasm Nucleus speckle Shuttles between nucleus and cytoplasm.
Detection Range	78-5000pg/mL
Entryname	WT1_MOUSE
Method Type	Competitive
Platform	PF02165
Protein Name	Wilms tumor protein homolog
Sensitivity	39.6pg/mL
Sequence	50: MGSDVRDLNA ; LLPAVSSLGG ; GGGGCGLPVS ; GARQWAPVLD ; FAPPGASAYG ; 100: SLGGPAPPPA ; PPPPPPPPHS ; FIKQEPSWGG ; AEPHEEQCLS ; AFTLHFSGQF ; 150: TGTAGACRYG ; PFGPPPPSQA ; SSGQARMFPN ; APYLPSCLES ; QPTIRNQGYS ; 200: TVTFDGAPSY ; GHTPSHHAAQ ; FPNHSFKHED ; PMGQQGSLGE ; QQYSVPPPVY ; 250: GCHTPTDSCT ; GSQALLLRTP ; YSSDNLYQMT ; SQLECMTWNQ ; MNLGATLKGM ; 300: AAGSSSSVKW ; TEGQSNHGIG ; YESENHTAPI ; LCGAQYRIHT ; HGVFRGIQDV ; 350: RRVSGVAPTL ; VRSASETSEK ; RPFMCAYPGC ; NKRYFKLSHL ; QMHSRKHTGE ; 400: KPYQCDFKDC ; ERRFSRSDQL ; KRHQRRHTGV ; KPFQCKTCQR ; KFSRSDHLKT ; 449: HTRTHTGKTS ; EKPFSCRWHS ; CQKKFARSDE ; LVRHHNMHQR ; NMTKLHVAL
Sequence Length	449
String	P22561
Sub Unit	Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP, FAM123B/WTX and SRY. Interacts with RBM4 (By similarity). Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with U2AF2. Interacts with HNRNPU via the zinc-finger region. Isoform 1 and isoform 3 interacts with CITED2.

Uniprot	P22561
Gene Name	Wt1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:22431
Unigene	Mm.389339

Reference	1. "Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development." Buckler A.J., Pelletier J., Haber D.A., Glaser T., Housman D.E. Mol. Cell. Biol.11:1707-1712(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4) 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "A non-AUG translational initiation event generates novel WT1 isoforms." Bruening W., Pelletier J. J. Biol. Chem.271:8646-8654(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;ALTERNATIVE SPLICING (ISOFORMS 5 AND 6) 4. "WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes." Davies R.C., Calvio C., Bratt E., Larsson S.H., Lamond A.I., Hastie N.D. Genes Dev.12:3217-3225(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH U2AF2 5. "The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes." Niksic M., Slight J., Sanford J.R., Caceres J.F., Hastie N.D. Hum. Mol. Genet.13:463-471(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;RNA-BINDING;INTERACTION WITH POLYSOMES 6. "A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus." Srichai M.B., Konieczkowski M., Padiyar A., Konieczkowski D.J., Mukherjee A., Hayden P.S., Kamat S., El-Meanawy M.A., Khan S., Mundel P., Lee S.B., Bruggeman L.A., Schelling J.R., Sedor J.R. J. Biol. Chem.279:14398-14408(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WTIP 7. "The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain." Morrison A.A., Venables J.P., Dellaire G., Ladomery M.R. Biochem. Cell Biol.84:789-798(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 8. "Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene." Dame C., Kirschner K.M., Bartz K.V., Wallach T., Hussels C.S., Scholz H. Blood107:4282-4290(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY 9. "The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene." Kirschner K.M., Wagner N., Wagner K.-D., Wellmann S., Scholz H. J. Biol. Chem.281:31930-31939(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 10. "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage." Val P., Martinez-Barbera J.P., Swain A. Development134:2349-2358(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CITED2;DEVELOPMENTAL STAGE 11. "hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation." Spraggon L., Dudnakova T., Slight J., Lustig-Yariv O., Cotterell J., Hastie N., Miles C. Oncogene26:1484-1491(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HNRNPU;SUBCELLULAR LOCATION 12. "The transcription co-factor CITED2 functions during sex determination and early gonad development." Buaas F.W., Val P., Swain A. Hum. Mol. Genet.18:2989-3001(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE

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