Outer mitochondrial membrane protein porin 1 ; Plasmalemmal porin ; Voltage-dependent anion-selective channel protein 5 ; VDAC-5 ; Vdac5
Categories
Elisa
Function
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Specificity
Natural and recombinant Mouse Voltage-dependent anion-selective channel protein 1
Subcellular Location
Isoform Pl-VDAC1 Cell membrane Multi-pass membrane protein