JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Ubiquitin-protein ligase E3A

SKU : BHE13810920

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E9055m
Alternative Names	HECT-type ubiquitin transferase E3A ; Oncogenic protein-associated protein E6-AP
Categories	Elisa
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.
Specificity	Natural and recombinant Mouse Ubiquitin-protein ligase E3A
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.625-40ng/mL
Entryname	UBE3A_MOUSE
Method Type	Sandwich
Platform	PF00632
Protein Name	Ubiquitin-protein ligase E3A
Sensitivity	0.335 ng/mL
Sequence	50: MFLISDSKLL ; SPSCHRMATA ; CKSSPGESQS ; EDIEASRMKR ; AAAKHLIERY ; 100: YHQLTEGCGN ; EACTNEFCAS ; CPTFLRMDNN ; AAAIKALELY ; KINAKLCDPH ; 150: PSKKGASSAY ; LENSKGASNN ; SEIKMNKKEG ; KDFKDVIYLT ; EEKVYEIYEF ; 200: CRESEDYSPL ; IRVIGRIFSS ; AEALVLSFRK ; VKQHTKDELK ; SLQEKDEDKD ; 250: EDEKEKAACS ; AAAMEEDSEA ; SSSRMGDSSQ ; GDNNVQKLGP ; DDVTVDIDAI ; 300: RRVYSSLLAN ; EKLETAFLNA ; LVYLSPNVEC ; DLTYHNVYTR ; DPNYLNLFII ; 350: LMENSNLHSP ; EYLEMALPLF ; CKAMCKLPLE ; AQGKLIRLWS ; KYTADQIRRM ; 400: METFQQLITY ; KVISNEFNSR ; NLVNDDDAIV ; AASNCLKMVY ; YANVVGGDVD ; 450: TNHNEEDDEE ; PIPESSELTL ; QELLGDERRN ; KKGPRVDPLE ; TELGVKTLDC ; 500: RKPLISFEES ; INEPLNDVLE ; MDKDYTFFKV ; ETENKGSFMT ; CPFILNAVTK ; 550: NLGLYYDNRI ; RMYSERRITV ; LYSLVQGQQL ; NPYLTLKVRR ; DHIIDDALVR ; 600: LEMIAMENPA ; DLKKQLYVEF ; EGEQGVDEGG ; VSKEFFQLVV ; EEIFNPDIGM ; 650: FTYDEATKLF ; WFNPSSFETE ; GQFTLIGILG ; LAIYNNCILD ; VHFPMVVYRK ; 700: LMGKKGTFRD ; LGDSHPVLYQ ; SLKDLLEYEG ; SVEDDMMITF ; QISQTDLFGN ; 750: PMMYDLKENG ; DKIPITNENR ; KEFVISYSDY ; ILNKSVEKQF ; KAFRRGFHMV ; 800: TNESPLKYLF ; RPEEIELLIC ; GSRNLDFQAL ; EETTEYDGGY ; TRESVVIREF ; 850: WEIVHSFTDE ; QKRLFLLFTT ; GTDRAPVGGL ; GKLKMIIAKN ; GPDTERLPTS ; 885: HTCFNVLLLP ; EYSSKEKLNV ; RLLKAITYAK ; GFGML
Sequence Length	885
String	O08759
Sub Unit	Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with BPY2.

Uniprot	O08759
Gene Name	Ube3a
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.9002

Reference	1. "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases." Hatakeyama S., Jensen J.P., Weissman A.M. J. Biol. Chem.272:15085-15092(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION strain: C57BL/6 X CBA. 2. "The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region." Sutcliffe J.S., Jiang Y.-H., Galjaard R.-J., Matsuura T., Fang P., Kubota T., Christian S.L., Bressler J., Cattanach B., Ledbetter D.H., Beaudet A.L. Genome Res.7:368-377(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: BALB/c. tissue: Brain. 3. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver. 4. "The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor." Gossan N.C., Zhang F., Guo B., Jin D., Yoshitane H., Yao A., Glossop N., Zhang Y.Q., Fukada Y., Meng Q.J. Nucleic Acids Res.42:5765-5775(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13810920	E9055m	96T	$776		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.