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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Tyrosine-protein kinase JAK3

SKU : BHE13805923

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0425m
Alternative Names	Janus kinase 3 ; JAK-3
Categories	Elisa
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Specificity	Natural and recombinant Mouse Tyrosine-protein kinase JAK3
Subcellular Location	Endomembrane system Peripheral membrane protein Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	JAK3_MOUSE
Method Type	Sandwich
Platform	PF07714
Protein Name	Tyrosine-protein kinase JAK3
Sensitivity	0.09ng/mL
Sequence	50: MAPPSEETPL ; IPQRSCSLSS ; SEAGALHVLL ; PPRGPGPPQR ; LSFSFGDYLA ; 100: EDLCVRAAKA ; CGILPVYHSL ; FALATEDFSC ; WFPPSHIFCI ; EDVDTQVLVY ; 150: RLRFYFPDWF ; GLETCHRFGL ; RKDLTSAILD ; LHVLEHLFAQ ; HRSDLVSGRL ; 200: PVGLSMKEQG ; EFLSLAVLDL ; AQMAREQAQR ; PGELLKTVSY ; KACLPPSLRD ; 250: VIQGQNFVTR ; RRIRRTVVLA ; LRRVVACQAD ; RYALMAKYIL ; DLERLHPAAT ; 300: TETFRVGLPG ; AQEEPGLLRV ; AGDNGISWSS ; GDQELFQTFC ; DFPEIVDVSI ; 350: KQAPRVGPAG ; EHRLVTVTRM ; DGHILEAEFP ; GLPEALSFVA ; LVDGYFRLIC ; 400: DSRHYFCKEV ; APPRLLEEEA ; ELCHGPITLD ; FAIHKLKAAG ; SLPGTYILRR ; 450: SPQDYDSFLL ; TACVQTPLGP ; DYKGCLIRQD ; PSGAFSLVGL ; SQPHRSLREL ; 500: LAACWNSGLR ; VDGAALNLTS ; CCAPRPKEKS ; NLIVVRRGCT ; PAPAPGCSPS ; 550: CCALTQLSFH ; TIPTDSLEWH ; ENLGHGSFTK ; IFRGRRREVV ; DGETHDSEVL ; 600: LKVMDSRHRN ; CMESFLEAAS ; LMSQVSYPHL ; VLLHGVCMAG ; DSIMVQEFVY ; 650: LGAIDMYLRK ; RGHLVSASWK ; LQVTKQLAYA ; LNYLEDKGLP ; HGNVSARKVL ; 700: LAREGGDGNP ; PFIKLSDPGV ; SPTVLSLEML ; TDRIPWVAPE ; CLQEAQTLCL ; 750: EADKWGFGAT ; TWEVFSGGPA ; HITSLEPAKK ; LKFYEDQGQL ; PALKWTELAG ; 800: LITQCMAYDP ; GRRPSFRAIL ; RDLNGLITSD ; YELLSDPTPG ; IPSPRDELCG ; 850: GAQLYACQDP ; AIFEERHLKY ; ISLLGKGNFG ; SVELCRYDPL ; GDNTGPLVAV ; 900: KQLQHSGPDQ ; QRDFQREIQI ; LKALHSDFIV ; KYRGVSYGPG ; RQSLRLVMEY ; 950: LPSGCLRDFL ; QRHRARLHTD ; RLLLFAWQIC ; KGMEYLGARR ; CVHRDLAARN ; 1000: ILVESEAHVK ; IADFGLAKLL ; PLGKDYYVVR ; EPGQSPIFWY ; APESLSDNIF ; 1050: SRQSDVWSFG ; VVLYELFTYC ; DKSCSPSAEF ; LRMMGPEREG ; PPLCRLLELL ; 1100:
Sequence Length	1100
String	Q62137
Sub Unit	Interacts with STAM2 and MYO18A. Interacts with SHB.

Uniprot	Q62137
Gene Name	Jak3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16453
Unigene	Mm.249645

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805923	E0425m	96T	$776		Add to Cart

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